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How the ends signal the end: Regulation by E3 ubiquitin ligases recognizing protein termini

Specificity of eukaryotic protein degradation is determined by E3 ubiquitin ligases and their selective binding to protein motifs, termed “degrons,” in substrates for ubiquitin-mediated proteolysis. From the discovery of the first substrate degron and the corresponding E3 to a flurry of recent studi...

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Detalles Bibliográficos
Autores principales: Sherpa, Dawafuti, Chrustowicz, Jakub, Schulman, Brenda A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9098119/
https://www.ncbi.nlm.nih.gov/pubmed/35247307
http://dx.doi.org/10.1016/j.molcel.2022.02.004