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High Yielding Continuous-Flow Synthesis of Norketamine

[Image: see text] A new continuous-flow process is presented for synthesis of the pharmaceutical intermediate norketamine (5). Our approach has been to take the well-established and industrially applied batch synthetic route to this promising antidepressant precursor and convert it to a telescoped m...

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Detalles Bibliográficos
Autores principales:	Hernando, Marcos Veguillas, Moore, Jonathan C., Howie, Rowena A., Castledine, Richard A., Bourne, Samuel L., Jenkins, Gareth N., Licence, Peter, Poliakoff, Martyn, George, Michael W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2022
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9098192/ https://www.ncbi.nlm.nih.gov/pubmed/35573033 http://dx.doi.org/10.1021/acs.oprd.1c00407

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