Cargando…

Thioredoxin-Interacting Protein (TXNIP) Knockdown Protects against Sepsis-Induced Brain Injury and Cognitive Decline in Mice by Suppressing Oxidative Stress and Neuroinflammation

Sepsis-associated encephalopathy (SAE) is linked to increased morbidity and mortality rates in patients with sepsis. Increased cytokine production and neuronal apoptosis are implicated in the pathogenesis of the SAE. Neuroinflammation plays a major role in sepsis-induced brain injury. Thioredoxin-in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Yu, Xing, Cheng-Jun, Liu, Xiao, Li, Ya-Hong, Jia, Jing, Feng, Jian-Guo, Yang, Cheng-Jie, Chen, Ye, Zhou, Jun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9098358/ https://www.ncbi.nlm.nih.gov/pubmed/35571246 http://dx.doi.org/10.1155/2022/8645714

Ejemplares similares

Activation of LRP1 Ameliorates Cerebral Ischemia/Reperfusion Injury and Cognitive Decline by Suppressing Neuroinflammation and Oxidative Stress through TXNIP/NLRP3 Signaling Pathway in Mice
por: Yang, Cheng-Jie, et al.
Publicado: (2022)

Nitrosative/Oxidative Stress Conditions Regulate Thioredoxin-Interacting Protein (TXNIP) Expression and Thioredoxin-1 (TRX-1) Nuclear Localization
por: Ogata, Fernando Toshio, et al.
Publicado: (2013)

ODP251 Thioredoxin-Interacting Protein (Txnip) And Cellular Senescence: Potential Adverse Effects of Txnip Deficiency.
por: Abubaker, Mohammed, et al.
Publicado: (2022)

Thioredoxin/Txnip: Redoxisome, as a Redox Switch for the Pathogenesis of Diseases
por: Yoshihara, Eiji, et al.
Publicado: (2014)

Thioredoxin-Interacting Protein (TXNIP) with Focus on Brain and Neurodegenerative Diseases
por: Tsubaki, Haruka, et al.
Publicado: (2020)

A role for thioredoxin-interacting protein (Txnip) in cellular creatine homeostasis
por: Zervou, Sevasti, et al.
Publicado: (2013)

Thioredoxin-Interacting Protein (TXNIP) Suppresses Expression of Glutamine Synthetase by Inducing Oxidative Stress in Retinal Muller Glia Under Diabetic Conditions
por: Zhou, Jia, et al.
Publicado: (2016)

Thioredoxin interacting protein (TXNIP) is a novel tumor suppressor in thyroid cancer
por: Morrison, Jennifer A, et al.
Publicado: (2014)

Upregulation of miR-20b Protects Against Cerebral Ischemic Stroke by Targeting Thioredoxin Interacting Protein (TXNIP)
por: Yang, Dejiang, et al.
Publicado: (2021)

Ezetimibe Attenuates Oxidative Stress and Neuroinflammation via the AMPK/Nrf2/TXNIP Pathway after MCAO in Rats
por: Yu, Jing, et al.
Publicado: (2020)

Thioredoxin binding protein (TBP)-2/Txnip and α-arrestin proteins in cancer and diabetes mellitus
por: Masutani, Hiroshi, et al.
Publicado: (2012)

Sirtuin 3 protects against anesthesia/surgery-induced cognitive decline in aged mice by suppressing hippocampal neuroinflammation
por: Liu, Qiang, et al.
Publicado: (2021)

Thioredoxin interacting protein (TXNIP) regulates tubular autophagy and mitophagy in diabetic nephropathy through the mTOR signaling pathway
por: Huang, Chunling, et al.
Publicado: (2016)

Hyperglycemia regulates thioredoxin-ROS activity through induction of thioredoxin-interacting protein (TXNIP) in metastatic breast cancer-derived cells MDA-MB-231
por: Turturro, Francesco, et al.
Publicado: (2007)

Fisetin ameliorates cognitive impairment by activating mitophagy and suppressing neuroinflammation in rats with sepsis‐associated encephalopathy
por: Ding, Hongguang, et al.
Publicado: (2021)

Dataset on the formation of Thioredoxin interacting protein (Txnip) containing redox sensitive high molecular weight nucleoprotein complexes
por: Hirata, Cristiane Lumi, et al.
Publicado: (2019)

N-Lobe of TXNIP Is Critical in the Allosteric Regulation of NLRP3 via TXNIP Binding
por: Cheng, Fengyu, et al.
Publicado: (2022)

Role of TXNIP/NLRP3 in sepsis-induced myocardial dysfunction
por: Yang, Chun, et al.
Publicado: (2019)

Icariin Ameliorates Palmitate-Induced Insulin Resistance Through Reducing Thioredoxin-Interacting Protein (TXNIP) and Suppressing ER Stress in C2C12 Myotubes
por: Li, Mingxin, et al.
Publicado: (2018)

AMP-Activated Protein Kinase (AMPK) Mediates Nutrient Regulation of Thioredoxin-Interacting Protein (TXNIP) in Pancreatic Beta-Cells
por: Shaked, Maayan, et al.
Publicado: (2011)

Long-Term IGF1 Stimulation Leads to Cellular Senescence via Functional Interaction with the Thioredoxin-Interacting Protein, TXNIP
por: Nagaraj, Karthik, et al.
Publicado: (2022)

Hydrocortisone Mitigates Alzheimer’s-Related Cognitive Decline through Modulating Oxidative Stress and Neuroinflammation
por: Li, Jinran, et al.
Publicado: (2023)

Thioredoxin in Post-Injury Sepsis And Ards
por: Eriksson, J, et al.
Publicado: (2015)

Retraction: Icariin ameliorates palmitate-induced insulin resistance through reducing thioredoxin-interacting protein (TXNIP) and suppressing ER stress in C2C12 myotubes
Publicado: (2023)

Correction: AMP-Activated Protein Kinase (AMPK) Mediates Nutrient Regulation of Thioredoxin-Interacting Protein (TXNIP) in Pancreatic Beta-Cells
por: Shaked, Maayan, et al.
Publicado: (2012)

Deletion of Thioredoxin Interacting Protein (TXNIP) Augments Hyperoxia-Induced Vaso-Obliteration in a Mouse Model of Oxygen Induced-Retinopathy
por: Abdelsaid, Mohammed A., et al.
Publicado: (2014)

Palmitate and insulin counteract glucose-induced thioredoxin interacting protein (TXNIP) expression in insulin secreting cells via distinct mechanisms
por: Panse, Madhura, et al.
Publicado: (2018)

Thioredoxin-1 distinctly promotes NF-κB target DNA binding and NLRP3 inflammasome activation independently of Txnip
por: Muri, Jonathan, et al.
Publicado: (2020)

Oxidative stress-mediated TXNIP loss causes RPE dysfunction
por: Ji Cho, Min, et al.
Publicado: (2019)

TXNIP Suppresses the Osteochondrogenic Switch of Vascular Smooth Muscle Cells in Atherosclerosis
por: Woo, Sang-Ho, et al.
Publicado: (2022)

Thioredoxin-Interacting-Protein [TXNIP] and Transglutaminase 2 [TGM2] Expression in Meningiomas of Different Grades and the Role of Their Expression in Meningioma Recurrence and Prognosis
por: Harb, Ola A, et al.
Publicado: (2017)

Modulating Expression of Thioredoxin Interacting Protein (TXNIP) Prevents Secondary Damage and Preserves Visual Function in a Mouse Model of Ischemia/Reperfusion
por: Coucha, Maha, et al.
Publicado: (2019)

(−)-Epicatechin Reduces Neuroinflammation, Protects Mitochondria Function, and Prevents Cognitive Impairment in Sepsis-Associated Encephalopathy
por: Ling, Jianmin, et al.
Publicado: (2022)

Systemic Response to Infection Induces Long-Term Cognitive Decline: Neuroinflammation and Oxidative Stress as Therapeutical Targets
por: Reis, Patricia Alves, et al.
Publicado: (2022)

Protective Effects of Bacillus coagulans JA845 against D-Galactose/AlCl(3)-Induced Cognitive Decline, Oxidative Stress and Neuroinflammation
por: Song, Xinping, et al.
Publicado: (2022)

Knockdown of RNF2 induces cell cycle arrest and apoptosis in prostate cancer cells through the upregulation of TXNIP
por: Wei, Ming, et al.
Publicado: (2016)

Thioredoxin-binding protein-2 (TBP-2/VDUP1/TXNIP) regulates T-cell sensitivity to glucocorticoid during HTLV-I-induced transformation
por: Chen, Z, et al.
Publicado: (2011)

The influence of gut microbiota alteration on age-related neuroinflammation and cognitive decline
por: Alsegiani, Amsha S., et al.
Publicado: (2022)

Asiatic Acid Protects Dopaminergic Neurons from Neuroinflammation by Suppressing Mitochondrial ROS Production
por: Chen, Dong, et al.
Publicado: (2019)

TXNIP Deficiency Exacerbates Endotoxic Shock via the Induction of Excessive Nitric Oxide Synthesis
por: Park, Young-Jun, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_o1ckb78mf0ma3kqfk5e6ppq4qv