UBR5 targets tumor suppressor CDC73 proteolytically to promote aggressive breast cancer

UBR5, a HECT-domain E3 ubiquitin ligase, is an attractive therapeutic target for aggressive breast cancers. Defining the substrates of UBR5 is crucial for scientific understanding and clinical intervention. Here, we demonstrate that CDC73, a component of the RNA polymerase II-associated factor 1 com...

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Detalles Bibliográficos
Autores principales: Xiang, Gang, Wang, Shuxuan, Chen, Ling, Song, Mei, Song, Xiaoxu, Wang, Huan, Zhou, Pengbo, Ma, Xiaojing, Yu, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9098409/
https://www.ncbi.nlm.nih.gov/pubmed/35551175
http://dx.doi.org/10.1038/s41419-022-04914-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9098409/
https://www.ncbi.nlm.nih.gov/pubmed/35551175
http://dx.doi.org/10.1038/s41419-022-04914-6

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