GFI1 regulates hair cell differentiation by acting as an off-DNA transcriptional co-activator of ATOH1, and a DNA-binding repressor

GFI1 is a zinc finger transcription factor that is necessary for the differentiation and survival of hair cells in the cochlea. Deletion of Gfi1 in mice significantly reduces the expression of hundreds of hair cell genes: this is a surprising result, as GFI1 normally acts as a transcriptional repres...

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Detalles Bibliográficos
Autores principales: Jen, Hsin-I, Singh, Sunita, Tao, Litao, Maunsell, Helen R., Segil, Neil, Groves, Andrew K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9098437/
https://www.ncbi.nlm.nih.gov/pubmed/35551236
http://dx.doi.org/10.1038/s41598-022-11931-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9098437/
https://www.ncbi.nlm.nih.gov/pubmed/35551236
http://dx.doi.org/10.1038/s41598-022-11931-0

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