Site-specific photolabile roadblocks for the study of transcription elongation in biologically complex systems

Transcriptional pausing is crucial for the timely expression of genetic information. Biochemical methods quantify the half-life of paused RNA polymerase (RNAP) by monitoring restarting complexes across time. However, this approach may produce apparent half-lives that are longer than true pause escap...

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Detalles Bibliográficos
Autores principales: Nadon, Jean-François, Epshtein, Vitaly, Cameron, Etienne, Samatov, Mikhail R., Vasenko, Andrey S., Nudler, Evgeny, Lafontaine, Daniel A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9098449/
https://www.ncbi.nlm.nih.gov/pubmed/35552496
http://dx.doi.org/10.1038/s42003-022-03382-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9098449/
https://www.ncbi.nlm.nih.gov/pubmed/35552496
http://dx.doi.org/10.1038/s42003-022-03382-0

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