Sotatercept analog suppresses inflammation to reverse experimental pulmonary arterial hypertension

Sotatercept is an activin receptor type IIA-Fc (ActRIIA-Fc) fusion protein that improves cardiopulmonary function in patients with pulmonary arterial hypertension (PAH) by selectively trapping activins and growth differentiation factors. However, the cellular and molecular mechanisms of ActRIIA-Fc a...

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Detalles Bibliográficos
Autores principales: Joshi, Sachindra R., Liu, Jun, Bloom, Troy, Karaca Atabay, Elif, Kuo, Tzu-Hsing, Lee, Michael, Belcheva, Elitza, Spaits, Matthew, Grenha, Rosa, Maguire, Michelle C., Frost, Jeffrey L., Wang, Kathryn, Briscoe, Steven D., Alexander, Mark J., Herrin, Brantley R., Castonguay, Roselyne, Pearsall, R. Scott, Andre, Patrick, Yu, Paul B., Kumar, Ravindra, Li, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9098455/
https://www.ncbi.nlm.nih.gov/pubmed/35551212
http://dx.doi.org/10.1038/s41598-022-11435-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9098455/
https://www.ncbi.nlm.nih.gov/pubmed/35551212
http://dx.doi.org/10.1038/s41598-022-11435-x

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