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Sotatercept analog suppresses inflammation to reverse experimental pulmonary arterial hypertension
Sotatercept is an activin receptor type IIA-Fc (ActRIIA-Fc) fusion protein that improves cardiopulmonary function in patients with pulmonary arterial hypertension (PAH) by selectively trapping activins and growth differentiation factors. However, the cellular and molecular mechanisms of ActRIIA-Fc a...
Autores principales: | Joshi, Sachindra R., Liu, Jun, Bloom, Troy, Karaca Atabay, Elif, Kuo, Tzu-Hsing, Lee, Michael, Belcheva, Elitza, Spaits, Matthew, Grenha, Rosa, Maguire, Michelle C., Frost, Jeffrey L., Wang, Kathryn, Briscoe, Steven D., Alexander, Mark J., Herrin, Brantley R., Castonguay, Roselyne, Pearsall, R. Scott, Andre, Patrick, Yu, Paul B., Kumar, Ravindra, Li, Gang |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9098455/ https://www.ncbi.nlm.nih.gov/pubmed/35551212 http://dx.doi.org/10.1038/s41598-022-11435-x |
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