Assembly-defective Tembusu virus ectopically expressing capsid protein is an approach for live-attenuated flavivirus vaccine development

Live-attenuated vaccines (LAVs) represent a promising approach for flavivirus vaccine development. In the present study, we demonstrated a method for generating flavivirus LAVs based on breaking spatially and temporally regulated C-prM cleavage to disturb the viral assembly process, using an avian f...

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Detalles Bibliográficos
Autores principales: He, Yu, Guo, Jiaqi, Wang, Xiaoli, Zhang, Senzhao, Mao, Li, Hu, Tao, Wang, Mingshu, Jia, Renyong, Zhu, Dekang, Liu, Mafeng, Zhao, Xinxin, Yang, Qiao, Wu, Ying, Zhang, Shaqiu, Huang, Juan, Mao, Sai, Ou, Xumin, Gao, Qun, Sun, Di, Cheng, Anchun, Chen, Shun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9098475/
https://www.ncbi.nlm.nih.gov/pubmed/35550523
http://dx.doi.org/10.1038/s41541-022-00468-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9098475/
https://www.ncbi.nlm.nih.gov/pubmed/35550523
http://dx.doi.org/10.1038/s41541-022-00468-y

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