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Runx1 and Runx2 inhibit fibrotic conversion of cellular niches for hematopoietic stem cells

In bone marrow, special microenvironments, known as niches, are essential for the maintenance of hematopoietic stem cells (HSCs). A population of mesenchymal stem cells, termed CXC chemokine ligand 12 (CXCL12)-abundant reticular (CAR) cells or leptin receptor-expressing cells are the major cellular...

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Detalles Bibliográficos
Autores principales: Omatsu, Yoshiki, Aiba, Shota, Maeta, Tomonori, Higaki, Kei, Aoki, Kazunari, Watanabe, Hitomi, Kondoh, Gen, Nishimura, Riko, Takeda, Shu, Chung, Ung-il, Nagasawa, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9098511/
https://www.ncbi.nlm.nih.gov/pubmed/35551452
http://dx.doi.org/10.1038/s41467-022-30266-y