MRNIP condensates promote DNA double-strand break sensing and end resection

The rapid recognition of DNA double-strand breaks (DSBs) by the MRE11/RAD50/NBS1 (MRN) complex is critical for the initiation of DNA damage response and DSB end resection. Here, we show that MRN complex interacting protein (MRNIP) forms liquid-like condensates to promote homologous recombination-med...

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Detalles Bibliográficos
Autores principales: Wang, Yun-Long, Zhao, Wan-Wen, Bai, Shao-Mei, Feng, Li-Li, Bie, Shu-Ying, Gong, Li, Wang, Fang, Wei, Ming-Biao, Feng, Wei-Xing, Pang, Xiao-Lin, Qin, Cao-Litao, Yin, Xin-Ke, Wang, Ying-Nai, Zhou, Weihua, Wahl, Daniel R., Liu, Quentin, Chen, Ming, Hung, Mien-Chie, Wan, Xiang-Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9098523/
https://www.ncbi.nlm.nih.gov/pubmed/35551189
http://dx.doi.org/10.1038/s41467-022-30303-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9098523/
https://www.ncbi.nlm.nih.gov/pubmed/35551189
http://dx.doi.org/10.1038/s41467-022-30303-w

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