Poly-guanidine shows high cytotoxicity in glioma cell cultures and glioma stem cells

Glioblastoma multiforme (GBM) is a malignant CNS tumor with a poor prognosis. GBM shows aberrant glycosylation with hypersialylation. This property is a potential target for therapy. This study investigates the growth inhibitory efficacy of poly-guanidine (GuaDex), with an affinity for sialic acid (...

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Detalles Bibliográficos
Autores principales: Márquez, Marcela, Olausson, Karl Holmberg, Alaiya, Ayodele, Nilsson, Sten, Meurling, Lennart, Holmberg, Anders R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Preclinical Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9098561/
https://www.ncbi.nlm.nih.gov/pubmed/35312943
http://dx.doi.org/10.1007/s10637-022-01233-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9098561/
https://www.ncbi.nlm.nih.gov/pubmed/35312943
http://dx.doi.org/10.1007/s10637-022-01233-7

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