Integrated omics approach to unveil antifungal bacterial polyynes as acetyl-CoA acetyltransferase inhibitors

Bacterial polyynes are highly active natural products with a broad spectrum of antimicrobial activities. However, their detailed mechanism of action remains unclear. By integrating comparative genomics, transcriptomics, functional genetics, and metabolomics analysis, we identified a unique polyyne r...

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Detalles Bibliográficos
Autores principales: Lin, Ching-Chih, Hoo, Sin Yong, Ma, Li-Ting, Lin, Chih, Huang, Kai-Fa, Ho, Ying-Ning, Sun, Chi-Hui, Lee, Han-Jung, Chen, Pi-Yu, Shu, Lin-Jie, Wang, Bo-Wei, Hsu, Wei-Chen, Ko, Tzu-Ping, Yang, Yu-Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9098870/
https://www.ncbi.nlm.nih.gov/pubmed/35551233
http://dx.doi.org/10.1038/s42003-022-03409-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9098870/
https://www.ncbi.nlm.nih.gov/pubmed/35551233
http://dx.doi.org/10.1038/s42003-022-03409-6

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