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Microfluidics delivery of DARPP-32 into HeLa cells maintains viability for in-cell NMR spectroscopy
High-resolution structural studies of proteins and protein complexes in a native eukaryotic environment present a challenge to structural biology. In-cell NMR can characterize atomic resolution structures but requires high concentrations of labeled proteins in intact cells. Most exogenous delivery t...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9098904/ https://www.ncbi.nlm.nih.gov/pubmed/35551287 http://dx.doi.org/10.1038/s42003-022-03412-x |