Pharmacometabonomic association of cyclophosphamide 4‐hydroxylation in hematopoietic cell transplant recipients

The widely used alkylating agent cyclophosphamide (CY) has substantive interpatient variability in the area under the curve (AUC) of it and its metabolites. Numerous factors may influence the drug‐metabolizing enzymes that metabolize CY to 4‐hydroxycyclophosphamide (4HCY), the principal precursor to...

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Detalles Bibliográficos
Autores principales: McCune, Jeannine S., Nakamura, Ryotaro, O’Meally, Denis, Randolph, Timothy W., Sandmaier, Brenda M., Karolak, Aleksandra, Hockenbery, David, Navarro, Sandi L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9099130/
https://www.ncbi.nlm.nih.gov/pubmed/35106927
http://dx.doi.org/10.1111/cts.13239

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9099130/
https://www.ncbi.nlm.nih.gov/pubmed/35106927
http://dx.doi.org/10.1111/cts.13239

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