Apolipoprotein E4 Effects a Distinct Transcriptomic Profile and Dendritic Arbor Characteristics in Hippocampal Neurons Cultured in vitro

The APOE gene is diversified by three alleles ε2, ε3, and ε4 encoding corresponding apolipoprotein (apo) E isoforms. Possession of the ε4 allele is signified by increased risks of age-related cognitive decline, Alzheimer’s disease (AD), and the rate of AD dementia progression. ApoE is secreted by as...

Descripción completa

Detalles Bibliográficos
Autores principales: Diaz, Jenny R., Martá-Ariza, Mitchell, Khodadadi-Jamayran, Alireza, Heguy, Adriana, Tsirigos, Aristotelis, Pankiewicz, Joanna E., Sullivan, Patrick M., Sadowski, Martin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9099260/
https://www.ncbi.nlm.nih.gov/pubmed/35572125
http://dx.doi.org/10.3389/fnagi.2022.845291

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9099260/
https://www.ncbi.nlm.nih.gov/pubmed/35572125
http://dx.doi.org/10.3389/fnagi.2022.845291

Ejemplares similares