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A Novel Mechanism for SIRT1 Activators That Does Not Rely on the Chemical Moiety Immediately C-Terminal to the Acetyl-Lysine of the Substrate

SIRT1, an NAD(+)-dependent deacetylase, catalyzes the deacetylation of proteins coupled with the breakdown of NAD(+) into nicotinamide and 2′-O-acetyl-ADP-ribose (OAADPr). Selective SIRT1 activators have potential clinical applications in atherosclerosis, acute renal injury, and Alzheimer’s disease....

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Detalles Bibliográficos
Autores principales: Yu, Nian-Da, Wang, Bing, Li, Xin-Zhu, Han, Hao-Zhen, Liu, Dongxiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9099470/
https://www.ncbi.nlm.nih.gov/pubmed/35566069
http://dx.doi.org/10.3390/molecules27092714