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A Novel Mechanism for SIRT1 Activators That Does Not Rely on the Chemical Moiety Immediately C-Terminal to the Acetyl-Lysine of the Substrate
SIRT1, an NAD(+)-dependent deacetylase, catalyzes the deacetylation of proteins coupled with the breakdown of NAD(+) into nicotinamide and 2′-O-acetyl-ADP-ribose (OAADPr). Selective SIRT1 activators have potential clinical applications in atherosclerosis, acute renal injury, and Alzheimer’s disease....
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9099470/ https://www.ncbi.nlm.nih.gov/pubmed/35566069 http://dx.doi.org/10.3390/molecules27092714 |