One-Pot Synthesis of (E)-2-(3-Oxoindolin-2-ylidene)-2-arylacetonitriles

A highly efficient and expeditious one-pot approach towards 2-(3-oxoindolin-2-yl)acetonitriles was designed, which involves a base-assisted aldol reaction of ortho-nitroacetophenones, followed by hydrocyanation, triggering an unusual reductive cyclization reaction.

Detalles Bibliográficos
Autores principales: Aksenov, Nicolai A., Aksenov, Alexander V., Kurenkov, Igor A., Kirillov, Nikita K., Aksenov, Dmitrii A., Arutiunov, Nikolai A., Aksenova, Daria S., Rubin, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9099830/
https://www.ncbi.nlm.nih.gov/pubmed/35566159
http://dx.doi.org/10.3390/molecules27092808
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author Aksenov, Nicolai A.
Aksenov, Alexander V.
Kurenkov, Igor A.
Kirillov, Nikita K.
Aksenov, Dmitrii A.
Arutiunov, Nikolai A.
Aksenova, Daria S.
Rubin, Michael
author_facet Aksenov, Nicolai A.
Aksenov, Alexander V.
Kurenkov, Igor A.
Kirillov, Nikita K.
Aksenov, Dmitrii A.
Arutiunov, Nikolai A.
Aksenova, Daria S.
Rubin, Michael
author_sort Aksenov, Nicolai A.
collection PubMed
description A highly efficient and expeditious one-pot approach towards 2-(3-oxoindolin-2-yl)acetonitriles was designed, which involves a base-assisted aldol reaction of ortho-nitroacetophenones, followed by hydrocyanation, triggering an unusual reductive cyclization reaction.
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spelling pubmed-90998302022-05-14 One-Pot Synthesis of (E)-2-(3-Oxoindolin-2-ylidene)-2-arylacetonitriles Aksenov, Nicolai A. Aksenov, Alexander V. Kurenkov, Igor A. Kirillov, Nikita K. Aksenov, Dmitrii A. Arutiunov, Nikolai A. Aksenova, Daria S. Rubin, Michael Molecules Article A highly efficient and expeditious one-pot approach towards 2-(3-oxoindolin-2-yl)acetonitriles was designed, which involves a base-assisted aldol reaction of ortho-nitroacetophenones, followed by hydrocyanation, triggering an unusual reductive cyclization reaction. MDPI 2022-04-28 /pmc/articles/PMC9099830/ /pubmed/35566159 http://dx.doi.org/10.3390/molecules27092808 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Aksenov, Nicolai A.
Aksenov, Alexander V.
Kurenkov, Igor A.
Kirillov, Nikita K.
Aksenov, Dmitrii A.
Arutiunov, Nikolai A.
Aksenova, Daria S.
Rubin, Michael
One-Pot Synthesis of (E)-2-(3-Oxoindolin-2-ylidene)-2-arylacetonitriles
title One-Pot Synthesis of (E)-2-(3-Oxoindolin-2-ylidene)-2-arylacetonitriles
title_full One-Pot Synthesis of (E)-2-(3-Oxoindolin-2-ylidene)-2-arylacetonitriles
title_fullStr One-Pot Synthesis of (E)-2-(3-Oxoindolin-2-ylidene)-2-arylacetonitriles
title_full_unstemmed One-Pot Synthesis of (E)-2-(3-Oxoindolin-2-ylidene)-2-arylacetonitriles
title_short One-Pot Synthesis of (E)-2-(3-Oxoindolin-2-ylidene)-2-arylacetonitriles
title_sort one-pot synthesis of (e)-2-(3-oxoindolin-2-ylidene)-2-arylacetonitriles
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9099830/
https://www.ncbi.nlm.nih.gov/pubmed/35566159
http://dx.doi.org/10.3390/molecules27092808
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