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One-Pot Synthesis of (E)-2-(3-Oxoindolin-2-ylidene)-2-arylacetonitriles
A highly efficient and expeditious one-pot approach towards 2-(3-oxoindolin-2-yl)acetonitriles was designed, which involves a base-assisted aldol reaction of ortho-nitroacetophenones, followed by hydrocyanation, triggering an unusual reductive cyclization reaction.
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9099830/ https://www.ncbi.nlm.nih.gov/pubmed/35566159 http://dx.doi.org/10.3390/molecules27092808 |
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author | Aksenov, Nicolai A. Aksenov, Alexander V. Kurenkov, Igor A. Kirillov, Nikita K. Aksenov, Dmitrii A. Arutiunov, Nikolai A. Aksenova, Daria S. Rubin, Michael |
author_facet | Aksenov, Nicolai A. Aksenov, Alexander V. Kurenkov, Igor A. Kirillov, Nikita K. Aksenov, Dmitrii A. Arutiunov, Nikolai A. Aksenova, Daria S. Rubin, Michael |
author_sort | Aksenov, Nicolai A. |
collection | PubMed |
description | A highly efficient and expeditious one-pot approach towards 2-(3-oxoindolin-2-yl)acetonitriles was designed, which involves a base-assisted aldol reaction of ortho-nitroacetophenones, followed by hydrocyanation, triggering an unusual reductive cyclization reaction. |
format | Online Article Text |
id | pubmed-9099830 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-90998302022-05-14 One-Pot Synthesis of (E)-2-(3-Oxoindolin-2-ylidene)-2-arylacetonitriles Aksenov, Nicolai A. Aksenov, Alexander V. Kurenkov, Igor A. Kirillov, Nikita K. Aksenov, Dmitrii A. Arutiunov, Nikolai A. Aksenova, Daria S. Rubin, Michael Molecules Article A highly efficient and expeditious one-pot approach towards 2-(3-oxoindolin-2-yl)acetonitriles was designed, which involves a base-assisted aldol reaction of ortho-nitroacetophenones, followed by hydrocyanation, triggering an unusual reductive cyclization reaction. MDPI 2022-04-28 /pmc/articles/PMC9099830/ /pubmed/35566159 http://dx.doi.org/10.3390/molecules27092808 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Aksenov, Nicolai A. Aksenov, Alexander V. Kurenkov, Igor A. Kirillov, Nikita K. Aksenov, Dmitrii A. Arutiunov, Nikolai A. Aksenova, Daria S. Rubin, Michael One-Pot Synthesis of (E)-2-(3-Oxoindolin-2-ylidene)-2-arylacetonitriles |
title | One-Pot Synthesis of (E)-2-(3-Oxoindolin-2-ylidene)-2-arylacetonitriles |
title_full | One-Pot Synthesis of (E)-2-(3-Oxoindolin-2-ylidene)-2-arylacetonitriles |
title_fullStr | One-Pot Synthesis of (E)-2-(3-Oxoindolin-2-ylidene)-2-arylacetonitriles |
title_full_unstemmed | One-Pot Synthesis of (E)-2-(3-Oxoindolin-2-ylidene)-2-arylacetonitriles |
title_short | One-Pot Synthesis of (E)-2-(3-Oxoindolin-2-ylidene)-2-arylacetonitriles |
title_sort | one-pot synthesis of (e)-2-(3-oxoindolin-2-ylidene)-2-arylacetonitriles |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9099830/ https://www.ncbi.nlm.nih.gov/pubmed/35566159 http://dx.doi.org/10.3390/molecules27092808 |
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