Cargando…

EMT, Stemness, and Drug Resistance in Biological Context: A 3D Tumor Tissue/In Silico Platform for Analysis of Combinatorial Treatment in NSCLC with Aggressive KRAS-Biomarker Signatures

SIMPLE SUMMARY: The phenotypic transition of tumor cells from epithelial to mesenchymal characteristics is called EMT and is widely discussed in the scientific community as a game changer in drug resistance and metastasis formation. However, clinical studies could not prove the efficacy of EMT-inter...

Descripción completa

Detalles Bibliográficos
Autores principales:	Peindl, Matthias, Göttlich, Claudia, Crouch, Samantha, Hoff, Niklas, Lüttgens, Tamara, Schmitt, Franziska, Pereira, Jesús Guillermo Nieves, May, Celina, Schliermann, Anna, Kronenthaler, Corinna, Cheufou, Danjouma, Reu-Hofer, Simone, Rosenwald, Andreas, Weigl, Elena, Walles, Thorsten, Schüler, Julia, Dandekar, Thomas, Nietzer, Sarah, Dandekar, Gudrun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9099837/ https://www.ncbi.nlm.nih.gov/pubmed/35565305 http://dx.doi.org/10.3390/cancers14092176

Ejemplares similares

A combined tissue‐engineered/in silico signature tool patient stratification in lung cancer
por: Göttlich, Claudia, et al.
Publicado: (2018)

Establishment of a human 3D lung cancer model based on a biological tissue matrix combined with a Boolean in silico model
por: Stratmann, Anna T., et al.
Publicado: (2013)

Connecting Cancer Pathways to Tumor Engines: A Stratification Tool for Colorectal Cancer Combining Human In Vitro Tissue Models with Boolean In Silico Models
por: Baur, Florentin, et al.
Publicado: (2019)

Human Organotypic Lung Tumor Models: Suitable For Preclinical (18)F-FDG PET-Imaging
por: Fecher, David, et al.
Publicado: (2016)

Intralobar pulmonary sequestration: robotical resection using indocyanine green
por: Mohnke, Jonas, et al.
Publicado: (2023)

Mimicking Metastases Including Tumor Stroma: A New Technique to Generate a Three-Dimensional Colorectal Cancer Model Based on a Biological Decellularized Intestinal Scaffold
por: Nietzer, Sarah, et al.
Publicado: (2016)

Efficient Redirection of NK Cells by Genetic Modification with Chemokine Receptors CCR4 and CCR2B
por: Feigl, Frederik Fabian, et al.
Publicado: (2023)

Pulmonary manifestation of a condition resembling Kasabach–Merritt syndrome in a woman with abdominal angiomatosis associated with consumptive coagulopathy – surgical management: a case report
por: Cheufou, Danjouma Housmanou, et al.
Publicado: (2015)

Non-Coding RNAs in Lung Cancer: Contribution of Bioinformatics Analysis to the Development of Non-Invasive Diagnostic Tools
por: Kunz, Meik, et al.
Publicado: (2016)

Inhibition of TGF-β-receptor signaling augments the antitumor function of ROR1-specific CAR T-cells against triple-negative breast cancer
por: Stüber, Tanja, et al.
Publicado: (2020)

Potential Prognostic Value of Preoperative Leukocyte Count, Lactate Dehydrogenase and C-Reactive Protein in Thymic Epithelial Tumors
por: Valdivia, Daniel, et al.
Publicado: (2021)

Identifying functional modules in protein–protein interaction networks: an integrated exact approach
por: Dittrich, Marcus T., et al.
Publicado: (2008)

Cystic Artery: Morphological Study and Surgical Significance
por: Dandekar, Usha, et al.
Publicado: (2016)

Progeria and Aging—Omics Based Comparative Analysis
por: Caliskan, Aylin, et al.
Publicado: (2022)

Right Hepatic Artery: A Cadaver Investigation and Its Clinical Significance
por: Dandekar, Usha, et al.
Publicado: (2015)

Tissue Engineering of a Human 3D in vitro Tumor Test System
por: Moll, Corinna, et al.
Publicado: (2013)

In vitro skin culture media influence the viability and inflammatory response of primary macrophages
por: Griffoni, Chiara, et al.
Publicado: (2021)

Electrostatic hazards
por: Luttgens, Günter, et al.
Publicado: (1997)

Germinal Center B Cell-Like (GCB) and Activated B Cell-Like (ABC) Type of Diffuse Large B Cell Lymphoma (DLBCL): Analysis of Molecular Predictors, Signatures, Cell Cycle State and Patient Survival
por: Blenk, S., et al.
Publicado: (2007)

Support System for Mental Health Professionals*
por: Dandekar, Ajit
Publicado: (2015)

A combinatorially regulated RNA splicing signature predicts breast cancer EMT states and patient survival
por: Qiu, Yushan, et al.
Publicado: (2020)

Frequency of regulatory T cells determines the outcome of the T-cell-engaging antibody blinatumomab in patients with B-precursor ALL
por: Duell, J, et al.
Publicado: (2017)

Combinatorial approaches for mitigating resistance to KRAS-targeted therapies
por: Warren, Hannah R., et al.
Publicado: (2022)

Unraveling the Connection between Fibroblast Growth Factor and Bone Morphogenetic Protein Signaling
por: Schliermann, Anna, et al.
Publicado: (2018)

Development of 3D human intestinal equivalents for substance testing in microliter-scale on a multi-organ-chip
por: Jaenicke, Annika, et al.
Publicado: (2013)

Trans-splicing of pre-mRNA is predicted to occur in a wide range of organisms including vertebrates.
por: Dandekar, T, et al.
Publicado: (1990)

inGeno – an integrated genome and ortholog viewer for improved genome to genome comparisons
por: Liang, Chunguang, et al.
Publicado: (2006)

Lead expansion and virtual screening of Indinavir derivate HIV-1 protease inhibitors using pharmacophoric - shape similarity scoring function
por: Shityakov, Sergey, et al.
Publicado: (2010)

The Role of Auxin-Cytokinin Antagonism in Plant-Pathogen Interactions
por: Naseem, Muhammad, et al.
Publicado: (2012)

Convergence behaviour and Control in Non-Linear Biological Networks
por: Karl, Stefan, et al.
Publicado: (2015)

Host-adapted metabolism and its regulation in bacterial pathogens
por: Dandekar, Thomas, et al.
Publicado: (2015)

Jimena: efficient computing and system state identification for genetic regulatory networks
por: Karl, Stefan, et al.
Publicado: (2013)

MSL: Facilitating automatic and physical analysis of published scientific literature in PDF format
por: Ahmed, Zeeshan, et al.
Publicado: (2018)

Kinesiology : scientific basis of human motion
por: Luttgens, Kathryn
Publicado: (1997)

Explorative data analysis of MCL reveals gene expression networks implicated in survival and prognosis supported by explorative CGH analysis
por: Blenk, Steffen, et al.
Publicado: (2008)

A combinatorial strategy for treating KRAS mutant lung cancer
por: Manchado, Eusebio, et al.
Publicado: (2016)

Software JimenaE allows efficient dynamic simulations of Boolean networks, centrality and system state analysis
por: Kaltdorf, Martin, et al.
Publicado: (2023)

Combinatorial targeting of a specific EMT/MET network by macroH2A variants safeguards mesenchymal identity
por: Valakos, Dimitrios, et al.
Publicado: (2023)

Investigation on Ciliary Functionality of Different Airway Epithelial Cell Lines in Three-Dimensional Cell Culture
por: Lodes, Nina, et al.
Publicado: (2020)

Organ preservation strategies: Review of literature and their applicability in developing nations
por: Dandekar, Mitali, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_v6pchni77q4b4qkoo4p15bgns6