Prime Editor 3 Mediated Beta-Thalassemia Mutations of the HBB Gene in Human Erythroid Progenitor Cells

Recently developed Prime Editor 3 (PE3) has been implemented to induce genome editing in various cell types but has not been proven in human hematopoietic stem and progenitor cells. Using PE3, we successfully installed the beta-thalassemia (beta-thal) mutations in the HBB gene in the erythroid proge...

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Detalles Bibliográficos
Autores principales: Zhang, Haokun, Zhou, Qinlinglan, Chen, Hongyan, Lu, Daru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9099916/
https://www.ncbi.nlm.nih.gov/pubmed/35563395
http://dx.doi.org/10.3390/ijms23095002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9099916/
https://www.ncbi.nlm.nih.gov/pubmed/35563395
http://dx.doi.org/10.3390/ijms23095002

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