Cargando…

First Characterization of Human Dermal Fibroblasts Showing a Decreased Xylosyltransferase-I Expression Induced by the CRISPR/Cas9 System

Background: Xylosyltransferases-I and II (XT-I and XT-II) catalyze the initial and rate limiting step of the proteoglycan (PG) biosynthesis and therefore have an import impact on the homeostasis of the extracellular matrix (ECM). The reason for the occurrence of two XT-isoforms in all higher organis...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fischer, Bastian, Schmidt, Vanessa, Ly, Thanh-Diep, Kleine, Anika, Knabbe, Cornelius, Faust-Hinse, Isabel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9100032/ https://www.ncbi.nlm.nih.gov/pubmed/35563435 http://dx.doi.org/10.3390/ijms23095045

Ejemplares similares

The Impact of Inflammatory Stimuli on Xylosyltransferase-I Regulation in Primary Human Dermal Fibroblasts
por: Ly, Thanh-Diep, et al.
Publicado: (2022)

Human Xylosyltransferase I—An Important Linker between Acute Senescence and Fibrogenesis
por: Schmidt, Vanessa, et al.
Publicado: (2023)

microRNA-29b mediates fibrotic induction of human xylosyltransferase-I in human dermal fibroblasts via the Sp1 pathway
por: Riedel, Lara, et al.
Publicado: (2018)

The Human Myofibroblast Marker Xylosyltransferase-I: A New Indicator for Macrophage Polarization
por: Ly, Thanh-Diep, et al.
Publicado: (2022)

Understanding of arthrofibrosis: New explorative insights into extracellular matrix remodeling of synovial fibroblasts
por: Ly, Thanh-Diep, et al.
Publicado: (2023)

Identification of Putative Non-Substrate-Based XT-I Inhibitors by Natural Product Library Screening
por: Ly, Thanh-Diep, et al.
Publicado: (2020)

First description of the complete human xylosyltransferase-I promoter region
por: Faust, Isabel, et al.
Publicado: (2014)

Activin A-Mediated Regulation of XT-I in Human Skin Fibroblasts
por: Ly, Thanh-Diep, et al.
Publicado: (2020)

Human xylosyltransferases – mediators of arthrofibrosis? New pathomechanistic insights into arthrofibrotic remodeling after knee replacement therapy
por: Faust, Isabel, et al.
Publicado: (2015)

Large-Scaled Metabolic Profiling of Human Dermal Fibroblasts Derived from Pseudoxanthoma Elasticum Patients and Healthy Controls
por: Kuzaj, Patricia, et al.
Publicado: (2014)

Linking ABCC6 Deficiency in Primary Human Dermal Fibroblasts of PXE Patients to p21-Mediated Premature Cellular Senescence and the Development of a Proinflammatory Secretory Phenotype
por: Tiemann, Janina, et al.
Publicado: (2020)

Expression of xylosyltransferases I and II and their role in the pathogenesis of arthrofibrosis
por: Bernstein, Anke, et al.
Publicado: (2020)

Genetic Dissection of CRISPR-Cas9 Mediated Inheritance of Independently Targeted Alleles in Tobacco α-1,3-Fucosyltransferase 1 and β-1,2-Xylosyltransferase 1 Loci
por: Song, Hayoung, et al.
Publicado: (2022)

Structural Basis for the Initiation of Glycosaminoglycan Biosynthesis by Human Xylosyltransferase 1
por: Briggs, David C., et al.
Publicado: (2018)

Evidence of Long-Lasting Humoral and Cellular Immunity against SARS-CoV-2 Even in Elderly COVID-19 Convalescents Showing a Mild to Moderate Disease Progression
por: Fischer, Bastian, et al.
Publicado: (2021)

The Activation of JAK/STAT3 Signaling and the Complement System Modulate Inflammation in the Primary Human Dermal Fibroblasts of PXE Patients
por: Lindenkamp, Christopher, et al.
Publicado: (2023)

Effect of Xylosyltransferase-I Silencing on Implanting Growth of Salivary Pleomorphic Adenoma
por: Ren, Guiyun, et al.
Publicado: (2018)

Potential Transmission Pathways of Streptococcus gallolyticus subsp. gallolyticus
por: Dumke, Jessika, et al.
Publicado: (2015)

Incidence of elevated lipoprotein (a) levels in a large cohort of patients with cardiovascular disease
por: van Buuren, Frank, et al.
Publicado: (2017)

SARS-CoV-2 IgG seroprevalence in blood donors located in three different federal states, Germany, March to June 2020
por: Fischer, Bastian, et al.
Publicado: (2020)

Analysis of a German blood donor cohort reveals a high number of undetected SARS-CoV-2 infections and sex-specific differences in humoral immune response
por: Fischer, Bastian, et al.
Publicado: (2022)

Inactivation of the β(1,2)-xylosyltransferase and the α(1,3)-fucosyltransferase genes in Nicotiana tabacum BY-2 Cells by a Multiplex CRISPR/Cas9 Strategy Results in Glycoproteins without Plant-Specific Glycans
por: Mercx, Sébastien, et al.
Publicado: (2017)

Molecular cloning and characterization of a novel tomato xylosyltransferase specific for gentisic acid
por: Tárraga, Susana, et al.
Publicado: (2010)

Xylosyltransferase-I Regulates Glycosaminoglycan Synthesis during the Pathogenic Process of Human Osteoarthritis
por: Venkatesan, Narayanan, et al.
Publicado: (2012)

Complete genome and comparative analysis of Streptococcus gallolyticus subsp. gallolyticus, an emerging pathogen of infective endocarditis
por: Hinse, Dennis, et al.
Publicado: (2011)

Serum Xylosyltransferase Activity in Diabetic Patients as a Possible Marker of Reduced Proteoglycan Biosynthesis
por: Götting, Christian, et al.
Publicado: (2008)

Xylosyltransferase 2, a protein encoded on chromosome 17q, is involved in HTLV entry
por: Jensen, Stig M R, et al.
Publicado: (2011)

Notch-modifying xylosyltransferase-substrate complexes support an S(N)i-like retaining mechanism
por: Yu, Hongjun, et al.
Publicado: (2015)

Glucoside xylosyltransferase 2 as a diagnostic and prognostic marker in gastric cancer via comprehensive analysis
por: Zhao, Yunxia, et al.
Publicado: (2021)

An association between bilateral keratoconus in a patient with spondyloocular syndrome and xylosyltransferase II gene mutation
por: Fathi-Nieto, Sara, et al.
Publicado: (2022)

Complete Genome Sequence of the Streptococcus gallolyticus subsp. gallolyticus Strain DSM 16831
por: Grimm, Imke, et al.
Publicado: (2017)

Abstract QS39: Fibroblasts Show Attenuated Wound Healing in the Setting of Dermal Melanoma
por: da Silva, Oscar L., et al.
Publicado: (2019)

A combined strategy to detect plasma samples reliably with high anti-SARS-CoV-2 neutralizing antibody titers in routine laboratories
por: Fischer, Bastian, et al.
Publicado: (2021)

The core Cas1 protein of CRISPR-Cas I-B in Leptospira shows metal-tunable nuclease activity
por: Dixit, Bhuvan, et al.
Publicado: (2021)

Murine skin-derived multipotent papillary dermal fibroblast progenitors show germline potential in vitro
por: Ge, Wei, et al.
Publicado: (2023)

Synthetic CRISPR-Cas gene activators for transcriptional reprogramming in bacteria
por: Dong, Chen, et al.
Publicado: (2018)

Immortalization of primary marmoset skin fibroblasts by CRISPR-Cas9-mediated gene targeting
por: Jeong, Yeon-Ju, et al.
Publicado: (2022)

Silencing β1,2-xylosyltransferase in Transgenic Tomato Fruits Reveals xylose as Constitutive Component of Ige-Binding Epitopes
por: Paulus, Kathrin Elisabeth, et al.
Publicado: (2011)

Humoral and cellular immune response levels at a 1-year follow-up after mild COVID-19
por: Flieder, Tobias, et al.
Publicado: (2022)

Reshuffling yeast chromosomes with CRISPR/Cas9
por: Fleiss, Aubin, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_ur24d7cnjbk125g6botkucbnio