Inhibition of Human Urokinase-Type Plasminogen Activator (uPA) Enzyme Activity and Receptor Binding by DNA Aptamers as Potential Therapeutics through Binding to the Different Forms of uPA

Urokinase-type plasminogen activator is widely discussed as a marker for cancer prognosis and diagnosis and as a target for cancer therapies. Together with its receptor, uPA plays an important role in tumorigenesis, tumor progression and metastasis. In the present study, systematic evolution of liga...

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Detalles Bibliográficos
Autores principales: Dreymann, Nico, Wuensche, Julia, Sabrowski, Wiebke, Moeller, Anja, Czepluch, Denise, Vu Van, Dana, Fuessel, Susanne, Menger, Marcus M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9100121/
https://www.ncbi.nlm.nih.gov/pubmed/35563278
http://dx.doi.org/10.3390/ijms23094890

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9100121/
https://www.ncbi.nlm.nih.gov/pubmed/35563278
http://dx.doi.org/10.3390/ijms23094890

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