Physosmotic Induction of Chondrogenic Maturation Is TGF-β Dependent and Enhanced by Calcineurin Inhibitor FK506

Increasing extracellular osmolarity 100 mOsm/kg above plasma level to the physiological levels for cartilage induces chondrogenic marker expression and the differentiation of chondroprogenitor cells. The calcineurin inhibitor FK506 has been reported to modulate the hypertrophic differentiation of pr...

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Detalles Bibliográficos
Autores principales: Jahr, Holger, van der Windt, Anna E., Timur, Ufuk Tan, Baart, Esther B., Lian, Wei-Shiung, Rolauffs, Bernd, Wang, Feng-Sheng, Pufe, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9100228/
https://www.ncbi.nlm.nih.gov/pubmed/35563498
http://dx.doi.org/10.3390/ijms23095110

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9100228/
https://www.ncbi.nlm.nih.gov/pubmed/35563498
http://dx.doi.org/10.3390/ijms23095110

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