Development of 1-(4-(Substituted)piperazin-1-yl)-2-((2-((4-methoxybenzyl)thio)pyrimidin-4-yl)oxy)ethanones That Target Poly (ADP-Ribose) Polymerase in Human Breast Cancer Cells

A number of uracil amides cleave poly (ADP-ribose) polymerase and therefore novel thiouracil amide compounds were synthesized and screened for the loss of cell viability in a human-estrogen-receptor-positive breast cancer cell line. The synthesized compounds exhibited moderate to significant efficac...

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Detalles Bibliográficos
Autores principales: Deveshegowda, Suresha N., Metri, Prashant K., Shivakumar, Rashmi, Yang, Ji-Rui, Rangappa, Shobith, Swamynayaka, Ananda, Shanmugam, Muthu K., Nagaraja, Omantheswara, Madegowda, Mahendra, Babu Shubha, Priya, Chinnathambi, Arunachalam, Alharbi, Sulaiman Ali, Pandey, Vijay, Ahn, Kwang Seok, Lobie, Peter E., Basappa, Basappa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9100275/
https://www.ncbi.nlm.nih.gov/pubmed/35566199
http://dx.doi.org/10.3390/molecules27092848

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9100275/
https://www.ncbi.nlm.nih.gov/pubmed/35566199
http://dx.doi.org/10.3390/molecules27092848

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