Uncovering the Key Role of Distortion in Bioorthogonal Tetrazine Tools That Defy the Reactivity/Stability Trade-Off

[Image: see text] The tetrazine/trans-cyclooctene ligation stands out from the bioorthogonal toolbox due to its exceptional reaction kinetics, enabling multiple molecular technologies in vitro and in living systems. Highly reactive 2-pyridyl-substituted tetrazines have become state of the art for ti...

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Detalles Bibliográficos
Autores principales: Svatunek, Dennis, Wilkovitsch, Martin, Hartmann, Lea, Houk, K. N., Mikula, Hannes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9100665/
https://www.ncbi.nlm.nih.gov/pubmed/35500228
http://dx.doi.org/10.1021/jacs.2c01056

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9100665/
https://www.ncbi.nlm.nih.gov/pubmed/35500228
http://dx.doi.org/10.1021/jacs.2c01056

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