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Prenatal Choline Supplementation Alters One Carbon Metabolites in a Rat Model of Periconceptional Alcohol Exposure

Prenatal alcohol exposure disturbs fetal and placental growth and can alter DNA methylation (DNAm). Supplementation with the methyl donor choline can increase fetal and placental growth and restore DNAm, suggesting converging effects on one-carbon metabolism (1CM). We investigated the impact of peri...

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Detalles Bibliográficos
Autores principales: Steane, Sarah E., Kumar, Vinod, Cuffe, James S. M., Moritz, Karen M., Akison, Lisa K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9100923/
https://www.ncbi.nlm.nih.gov/pubmed/35565848
http://dx.doi.org/10.3390/nu14091874