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Perspective: Biochemical and Physical Constraints Associated With Preparing Thin Specimens for Single-Particle Cryo-EM

While many aspects of single-particle electron cryo-microscopy (cryo-EM) of biological macromolecules have reached a sophisticated level of development, this is not yet the case when it comes to preparing thin samples on specimen grids. As a result, there currently is considerable interest in achiev...

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Detalles Bibliográficos
Autores principales: Han, Bong-Gyoon, Armstrong, Max, Fletcher, Daniel A., Glaeser, Robert M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9100935/
https://www.ncbi.nlm.nih.gov/pubmed/35573724
http://dx.doi.org/10.3389/fmolb.2022.864829