An Antisense Oligonucleotide against a Splicing Enhancer Sequence within Exon 1 of the MSTN Gene Inhibits Pre-mRNA Maturation to Act as a Novel Myostatin Inhibitor

Antisense oligonucleotides (ASOs) are agents that modulate gene function. ASO-mediated out-of-frame exon skipping has been employed to suppress gene function. Myostatin, encoded by the MSTN gene, is a potent negative regulator of skeletal muscle growth. ASOs that induce skipping of out-of-frame exon...

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Detalles Bibliográficos
Autores principales: Maeta, Kazuhiro, Farea, Manal, Nishio, Hisahide, Matsuo, Masafumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9101285/
https://www.ncbi.nlm.nih.gov/pubmed/35563408
http://dx.doi.org/10.3390/ijms23095016

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9101285/
https://www.ncbi.nlm.nih.gov/pubmed/35563408
http://dx.doi.org/10.3390/ijms23095016

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