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Context-dependant enhancers as a reservoir of functional polymorphisms and epigenetic markers linked to alcohol use disorders and comorbidities

Alcohol use disorder (AUD) is one of the major causes of mortality and morbidity world-wide. It is estimated that 50% of the causes of AUD are heritable. Efforts to determine the genetic determinants governing AUD using genome wide association studies (GWAS) show that the most strongly associated SN...

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Detalles Bibliográficos
Autores principales: MacKenzie, Alasdair, Hay, Elizabeth A., McEwan, Andrew R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9101288/
https://www.ncbi.nlm.nih.gov/pubmed/35712020
http://dx.doi.org/10.1016/j.addicn.2022.100014