Cargando…

Downregulation of miR-122-5p Activates Glycolysis via PKM2 in Kupffer Cells of Rat and Mouse Models of Non-Alcoholic Steatohepatitis

Non-alcoholic steatohepatitis (NASH) has pathological characteristics similar to those of alcoholic hepatitis, despite the absence of a drinking history. The greatest threat associated with NASH is its progression to cirrhosis and hepatocellular carcinoma. The pathophysiology of NASH is not fully un...

Descripción completa

Detalles Bibliográficos
Autores principales:	Inomata, Yosuke, Oh, Jae-Won, Taniguchi, Kohei, Sugito, Nobuhiko, Kawaguchi, Nao, Hirokawa, Fumitoshi, Lee, Sang-Woong, Akao, Yukihiro, Takai, Shinji, Kim, Kwang-Pyo, Uchiyama, Kazuhisa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9101520/ https://www.ncbi.nlm.nih.gov/pubmed/35563621 http://dx.doi.org/10.3390/ijms23095230

Ejemplares similares

Organ-Specific MicroRNAs (MIR122, 137, and 206) Contribute to Tissue Characteristics and Carcinogenesis by Regulating Pyruvate Kinase M1/2 (PKM) Expression
por: Taniguchi, Kohei, et al.
Publicado: (2018)

PTBP1‐targeting microRNAs regulate cancer‐specific energy metabolism through the modulation of PKM1/M2 splicing
por: Taniguchi, Kohei, et al.
Publicado: (2020)

SRSF3, a Splicer of the PKM Gene, Regulates Cell Growth and Maintenance of Cancer-Specific Energy Metabolism in Colon Cancer Cells
por: Kuranaga, Yuki, et al.
Publicado: (2018)

A novel hamster nonalcoholic steatohepatitis model induced by a high-fat and high-cholesterol diet
por: Miyaoka, Yuta, et al.
Publicado: (2018)

Chemically modified MIR143-3p exhibited anti-cancer effects by impairing the KRAS network in colorectal cancer cells
por: Sugito, Nobuhiko, et al.
Publicado: (2022)

Chymase as a Novel Therapeutic Target in Acute Pancreatitis
por: Kuramoto, Toru, et al.
Publicado: (2021)

PKM2 and cancer: The function of PKM2 beyond glycolysis
por: DONG, GAOCHAO, et al.
Publicado: (2016)

Synthetic MIR143-3p Suppresses Cell Growth in Rhabdomyosarcoma Cells by Interrupting RAS Pathways Including PAX3–FOXO1
por: Sugito, Nobuhiko, et al.
Publicado: (2020)

Organ-specific PTB1-associated microRNAs determine expression of pyruvate kinase isoforms
por: Taniguchi, Kohei, et al.
Publicado: (2015)

The polarizable and reprogrammable identity of Kupffer cells in Nonalcoholic Steatohepatitis
por: Zahr, Tarik, et al.
Publicado: (2022)

Exosome‐delivered circRNA promotes glycolysis to induce chemoresistance through the miR‐122‐PKM2 axis in colorectal cancer
por: Wang, Xinyi, et al.
Publicado: (2020)

Surgical management of intraoperatively diagnosed portal annular pancreas: Two case reports
por: Abe, Nobutaka, et al.
Publicado: (2021)

Overexpressed miR-122-5p Promotes Cell Viability, Proliferation, Migration And Glycolysis Of Renal Cancer By Negatively Regulating PKM2
por: Wang, Shuai, et al.
Publicado: (2019)

MiR-145 negatively regulates Warburg effect by silencing KLF4 and PTBP1 in bladder cancer cells
por: Minami, Koichiro, et al.
Publicado: (2017)

Targeting microRNA-145-mediated progressive phenotypes of early bladder cancer in a molecularly defined in vivo model
por: Heishima, Kazuki, et al.
Publicado: (2023)

DEAD-Box Protein RNA-Helicase DDX6 Regulates the Expression of HER2 and FGFR2 at the Post-Transcriptional Step in Gastric Cancer Cells
por: Tajirika, Toshihiro, et al.
Publicado: (2018)

PTBP1-associated microRNA-1 and -133b suppress the Warburg effect in colorectal tumors
por: Taniguchi, Kohei, et al.
Publicado: (2016)

PKM2 coordinates glycolysis with mitochondrial fusion and oxidative phosphorylation
por: Li, Tong, et al.
Publicado: (2019)

Comparison of a chymase inhibitor and hyaluronic acid/carboxymethylcellulose (Seprafilm) in a novel peritoneal adhesion model in rats
por: Ozeki, Maiko, et al.
Publicado: (2019)

Analysis of Extracellular Vesicles in Gastric Juice from Gastric Cancer Patients
por: Kagota, Shuji, et al.
Publicado: (2019)

Surgical treatment of gastric venous congestion in association with extended resection of pancreas: a case report
por: Kagota, Shuji, et al.
Publicado: (2020)

Duodenal obstruction due to chronic pancreatitis of the pancreas tail treated by surgical intervention: A case report
por: Tomioka, Atsushi, et al.
Publicado: (2019)

A complete response to capecitabine and oxaliplatin chemotherapy in primary duodenal carcinoma with liver and nodal metastases: a case report
por: Hagihara, Seita, et al.
Publicado: (2018)

Potent antiproliferative effect of fatty‐acid derivative AIC‐47 on leukemic mice harboring BCR‐ABL mutation
por: Shinohara, Haruka, et al.
Publicado: (2019)

Tumor Tissue MIR92a and Plasma MIRs21 and 29a as Predictive Biomarkers Associated with Clinicopathological Features and Surgical Resection in a Prospective Study on Colorectal Cancer Patients
por: Fukada, Masahiro, et al.
Publicado: (2020)

Postoperative changes in plasma miR21‐5p as a novel biomarker for colorectal cancer recurrence: A prospective study
por: Fukada, Masahiro, et al.
Publicado: (2021)

A Novel Combination RNAi toward Warburg Effect by Replacement with miR-145 and Silencing of PTBP1 Induces Apoptotic Cell Death in Bladder Cancer Cells
por: Takai, Tomoaki, et al.
Publicado: (2017)

MicroRNA-122 regulates docetaxel resistance of prostate cancer cells by regulating PKM2
por: Zhu, Zhirong, et al.
Publicado: (2020)

MicroRNA-214 Promotes Apoptosis in Canine Hemangiosarcoma by Targeting the COP1-p53 Axis
por: Heishima, Kazuki, et al.
Publicado: (2015)

Impairment of K‐Ras signaling networks and increased efficacy of epidermal growth factor receptor inhibitors by a novel synthetic miR‐143
por: Akao, Yukihiro, et al.
Publicado: (2018)

PKM2 methylation by CARM1 activates aerobic glycolysis to promote tumorigenesis
por: Liu, Fabao, et al.
Publicado: (2017)

FOXM1D potentiates PKM2‐mediated tumor glycolysis and angiogenesis
por: Zhang, Wei, et al.
Publicado: (2021)

The usefulness of laparoscopic surgery for inguinal endometriosis
por: Mushiake, Shu, et al.
Publicado: (2023)

Single port access for laparoscopic lateral segmentectomy
por: Inoue, Yoshihiro, et al.
Publicado: (2017)

MicroRNA‐143/Musashi‐2/KRAS cascade contributes positively to carcinogenesis in human bladder cancer
por: Tsujino, Takuya, et al.
Publicado: (2019)

MicroRNA-122 affects cell aggressiveness and apoptosis by targeting PKM2 in human hepatocellular carcinoma
por: Xu, Qiuran, et al.
Publicado: (2021)

Antitumor Immunity Produced by the Liver Kupffer Cells, NK Cells, NKT Cells, and CD8(+) CD122(+) T Cells
por: Seki, Shuhji, et al.
Publicado: (2011)

PKM2-dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation
por: Xie, Min, et al.
Publicado: (2016)

PolG Inhibits Gastric Cancer Glycolysis and Viability by Suppressing PKM2 Phosphorylation
por: Lv, Mengzhu, et al.
Publicado: (2021)

Exploring the use of single-port surgery in the conservative management of hepatic portal vein gas: A case report
por: Taniguchi, Kohei, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_iu10j1sc9qoj4gupotd96ap12g