1-Hydroxy-2(1H)-pyridinone-Based Chelators with Potential Catechol O-Methyl Transferase Inhibition and Neurorescue Dual Action against Parkinson’s Disease

Two analogues of tolcapone where the nitrocatechol group has been replaced by a 1-hydroxy-2(1H)-pyridinone have been designed and synthesised. These compounds are expected to have a dual mode of action both beneficial against Parkinson’s disease: they are designed to be inhibitors of catechol O-meth...

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Detalles Bibliográficos
Autores principales: Bergin, Joseph C. J., Tan, Kean Kan, Nelson, Anya K., Amarandei, Cristina-Andreea, Hubscher-Bruder, Véronique, Brandel, Jérémy, Voinarovska, Varvara, Dejaegere, Annick, Stote, Roland H., Tétard, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9101691/
https://www.ncbi.nlm.nih.gov/pubmed/35566171
http://dx.doi.org/10.3390/molecules27092816

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9101691/
https://www.ncbi.nlm.nih.gov/pubmed/35566171
http://dx.doi.org/10.3390/molecules27092816

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