CDK4/6 inhibitors sensitize gammaherpesvirus-infected tumor cells to T-cell killing by enhancing expression of immune surface molecules

BACKGROUND: The two oncogenic human gammaherpesviruses, Kaposi sarcoma-associated herpesvirus (KSHV) and Epstein–Barr virus (EBV), both downregulate immune surface molecules, such as MHC-I, ICAM-1, and B7-2, enabling them to evade T-cell and natural killer cell immunity. Both also either encode for...

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Detalles Bibliográficos
Autores principales: Wu, Yiquan, Shrestha, Prabha, Heape, Natalie M., Yarchoan, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9101822/
https://www.ncbi.nlm.nih.gov/pubmed/35562811
http://dx.doi.org/10.1186/s12967-022-03400-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9101822/
https://www.ncbi.nlm.nih.gov/pubmed/35562811
http://dx.doi.org/10.1186/s12967-022-03400-z

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