Cargando…

Activation of Sigma-1 Receptor Alleviates ER-Associated Cell Death and Microglia Activation in Traumatically Injured Mice

Background: Endoplasmic reticulum (ER) stress and unfolded protein response (UPR) is associated with neuroinflammation and subsequent cell death following traumatic brain injury (TBI). The sigma-1 receptor (Sig-1R) acts as a dynamic pluripotent modulator of fundamental cellular processes at the mito...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shi, Mingming, Liu, Liang, Min, Xiaobin, Mi, Liang, Chai, Yan, Chen, Fanglian, Wang, Jianhao, Yue, Shuyuan, Zhang, Jianning, Deng, Quanjun, Chen, Xin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9102000/ https://www.ncbi.nlm.nih.gov/pubmed/35566476 http://dx.doi.org/10.3390/jcm11092348

Ejemplares similares

Sigma-1 Receptor: A Potential Therapeutic Target for Traumatic Brain Injury
por: Shi, Mingming, et al.
Publicado: (2021)

Neutrophil extracellular traps aggravate neuronal endoplasmic reticulum stress and apoptosis via TLR9 after traumatic brain injury
por: Mi, Liang, et al.
Publicado: (2023)

Inhibition of neutrophil extracellular trap formation attenuates NLRP1-dependent neuronal pyroptosis via STING/IRE1α pathway after traumatic brain injury in mice
por: Cao, Yiyao, et al.
Publicado: (2023)

Fluvoxamine alleviates ER stress via induction of Sigma-1 receptor
por: Omi, T, et al.
Publicado: (2014)

Abrocitinib Attenuates Microglia-Mediated Neuroinflammation after Traumatic Brain Injury via Inhibiting the JAK1/STAT1/NF-κB Pathway
por: Li, Tuo, et al.
Publicado: (2022)

PT576. Fluvoxamine alleviates ER stress via induction of Sigma-1 receptor.
por: Kudo, Takashi
Publicado: (2016)

Flow Cytometric Characterization of T Cell Subsets and Microglia After Repetitive Mild Traumatic Brain Injury in Rats
por: Bai, Ruojing, et al.
Publicado: (2017)

NLRP1 Inflammasomes: A Potential Target for the Treatment of Several Types of Brain Injury
por: Mi, Liang, et al.
Publicado: (2022)

Neuron-derived exosomes-transmitted miR-124-3p protect traumatically injured spinal cord by suppressing the activation of neurotoxic microglia and astrocytes
por: Jiang, Dongdong, et al.
Publicado: (2020)

Microglia Stimulation by Protein Extract of Injured Rat Spinal Cord. A Novel In vitro Model for Studying Activated Microglia
por: Hernández, Joaquim, et al.
Publicado: (2021)

Microglia processes associate with diffusely injured axons following mild traumatic brain injury in the micro pig
por: Lafrenaye, Audrey D., et al.
Publicado: (2015)

Procyanidins alleviates morphine tolerance by inhibiting activation of NLRP3 inflammasome in microglia
por: Cai, Yang, et al.
Publicado: (2016)

Inhibition of neutrophil extracellular trap formation ameliorates neuroinflammation and neuronal apoptosis via STING-dependent IRE1α/ASK1/JNK signaling pathway in mice with traumatic brain injury
por: Shi, Guihong, et al.
Publicado: (2023)

A Novel Blood Inflammatory Indicator for Predicting Deterioration Risk of Mild Traumatic Brain Injury
por: Ge, Xintong, et al.
Publicado: (2022)

Physical interactions between activated microglia and injured axons: do all contacts lead to phagocytosis?
por: Lafrenaye, Audrey D.
Publicado: (2016)

Microglia Activation as a Biomarker for Traumatic Brain Injury
por: Hernandez-Ontiveros, Diana G., et al.
Publicado: (2013)

Cottonseed oil alleviates ischemic stroke injury by inhibiting the inflammatory activation of microglia and astrocyte
por: Liu, Min, et al.
Publicado: (2020)

Chronic Sigma 1 receptor activation alleviates right ventricular dysfunction secondary to pulmonary arterial hypertension
por: Sun, Yazhou, et al.
Publicado: (2022)

Elamipretide alleviates pyroptosis in traumatically injured spinal cord by inhibiting cPLA2-induced lysosomal membrane permeabilization
por: Zhang, Haojie, et al.
Publicado: (2023)

Aldose reductase inhibition decelerates optic nerve degeneration by alleviating retinal microglia activation
por: Rao, Mishal, et al.
Publicado: (2023)

Rice bran derivatives alleviate microglia activation: possible involvement of MAPK pathway
por: Bhatia, Harsharan S., et al.
Publicado: (2016)

Activation of β2-Adrenergic Receptors in Microglia Alleviates Neuropathic Hypersensitivity in Mice
por: Damo, Elisa, et al.
Publicado: (2023)

Microglia provide structural resolution to injured dendrites after severe seizures
por: Eyo, Ukpong B., et al.
Publicado: (2021)

Inhibition of Exosome Release Alleviates Cognitive Impairment After Repetitive Mild Traumatic Brain Injury
por: Hu, Tianpeng, et al.
Publicado: (2022)

Blockade of sigma 1 receptors alleviates sensory signs of diabetic neuropathy in rats
por: Paniagua, N., et al.
Publicado: (2016)

Sigma‐1 receptor attenuates osteoclastogenesis by promoting ER‐associated degradation of SERCA2
por: Wei, Xiaoan, et al.
Publicado: (2022)

The polarization of microglia and infiltrated macrophages in the injured mice spinal cords: a dynamic analysis
por: Li, Jing-Lu, et al.
Publicado: (2023)

The Sigma-1 receptor is an ER-localized type II membrane protein
por: Sharma, Neeraj, et al.
Publicado: (2021)

Stabilization of Brain Mast Cells Alleviates LPS-Induced Neuroinflammation by Inhibiting Microglia Activation
por: Dong, Hongquan, et al.
Publicado: (2019)

PTP1B inhibitor alleviates deleterious microglial activation and neuronal injury after ischemic stroke by modulating the ER stress-autophagy axis via PERK signaling in microglia
por: Zhu, Yu, et al.
Publicado: (2021)

CCR2 deficiency alters activation of microglia subsets in traumatic brain injury
por: Somebang, Kerri, et al.
Publicado: (2021)

Sigma-1 Receptor Chaperone at the ER-Mitochondrion Interface Mediates the Mitochondrion-ER-Nucleus Signaling for Cellular Survival
por: Mori, Tomohisa, et al.
Publicado: (2013)

Microglia: A Potential Drug Target for Traumatic Axonal Injury
por: Huang, Xin, et al.
Publicado: (2021)

Increased Microglial Exosomal miR-124-3p Alleviates Neurodegeneration and Improves Cognitive Outcome after rmTBI
por: Ge, Xintong, et al.
Publicado: (2020)

RETREG1-mediated ER-phagy activation induced by glucose deprivation alleviates nucleus pulposus cell damage via ER stress pathway: RETREG1-mediated ER-phagy modulates NP cell damage
por: Luo, Rongjin, et al.
Publicado: (2022)

Kiwifruit Alleviates Learning and Memory Deficits Induced by Pb through Antioxidation and Inhibition of Microglia Activation In Vitro and In Vivo
por: Xue, Wei-Zhen, et al.
Publicado: (2017)

Social Reintegration of Traumatic Brain-Injured: The French Experience
por: Truelle, J.-L., et al.
Publicado: (2010)

Rapid Sequence Intubation in Traumatic Brain-injured Adults
por: Kramer, Nicholas, et al.
Publicado: (2018)

Sigma-1 Receptor Promotes Mitochondrial Bioenergetics by Orchestrating ER Ca(2+) Leak during Early ER Stress
por: Koshenov, Zhanat, et al.
Publicado: (2021)

PKCδ silencing alleviates saturated fatty acid induced ER stress by enhancing SERCA activity
por: Lai, Shujie, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_lva6t7qs74e9nnndl2tg1s7512