Generation of Isogenic hiPSCs with Targeted Edits at Multiple Intronic SNPs to Study the Effects of the Type 2 Diabetes Associated KCNQ1 Locus in American Indians

The top genetic association signal for type 2 diabetes (T2D) in Southwestern American Indians maps to intron 15 of KCNQ1, an imprinted gene. We aim to understand the biology whereby variation at this locus affects T2D specifically in this genomic background. To do so, we obtained human induced pluri...

Descripción completa

Detalles Bibliográficos
Autores principales: Nair, Anup K., Traurig, Michael, Sutherland, Jeff R., Muller, Yunhua L., Grellinger, Emma D., Saporito, Lucas, Nelson, Robert G., Bogardus, Clifton, Baier, Leslie J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9102014/
https://www.ncbi.nlm.nih.gov/pubmed/35563754
http://dx.doi.org/10.3390/cells11091446

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9102014/
https://www.ncbi.nlm.nih.gov/pubmed/35563754
http://dx.doi.org/10.3390/cells11091446

Ejemplares similares