Cloning and Functional Characterization of Dog OCT1 and OCT2: Another Step in Exploring Species Differences in Organic Cation Transporters

OCT1 and OCT2 are polyspecific membrane transporters that are involved in hepatic and renal drug clearance in humans and mice. In this study, we cloned dog OCT1 and OCT2 and compared their function to the human and mouse orthologs. We used liver and kidney RNA to clone dog OCT1 and OCT2. The cloned...

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Detalles Bibliográficos
Autores principales: Meyer, Marleen Julia, Falk, Simon, Römer, Sarah, Prinzinger, Clarissa, Tacke, Sabine, Geyer, Joachim, Simm, Stefan, Tzvetkov, Mladen Vassilev
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9102066/
https://www.ncbi.nlm.nih.gov/pubmed/35563491
http://dx.doi.org/10.3390/ijms23095100

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9102066/
https://www.ncbi.nlm.nih.gov/pubmed/35563491
http://dx.doi.org/10.3390/ijms23095100

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