Is P-Glycoprotein Functionally Expressed in the Limiting Membrane of Endolysosomes? A Biochemical and Ultrastructural Study in the Rat Liver

The drug efflux transporter P-glycoprotein (Pgp; ABCB1) plays an important role in drug absorption, disposition, and elimination. There is an ongoing debate whether, in addition to its localization at the plasma membrane, Pgp may also be expressed at the limiting membrane of endolysosomes (ELs), med...

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Detalles Bibliográficos
Autores principales: Gericke, Birthe, Wienböker, Inka, Brandes, Gudrun, Löscher, Wolfgang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9102269/
https://www.ncbi.nlm.nih.gov/pubmed/35563868
http://dx.doi.org/10.3390/cells11091556

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9102269/
https://www.ncbi.nlm.nih.gov/pubmed/35563868
http://dx.doi.org/10.3390/cells11091556

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