Cationic N,N-Dimethylglycine Ester Prodrug of 2R-α-Tocotrienol Promotes Intestinal Absorption via Efficient Self-Micellization with Intrinsic Bile Acid Anion

The intestinal absorption of hydrophobic compounds is severely influenced by their transportation rate through the unstirred water layer in the intestinal lumen. A member of the vitamin E family, α-Tocotrienol (α-T3) has remarkable pharmacological effects, but its intestinal absorption is hampered d...

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Detalles Bibliográficos
Autores principales: Watase, Daisuke, Setoguchi, Shuichi, Nagata-Akaho, Nami, Goto, Shotaro, Yamakawa, Hirofumi, Yamada, Ayano, Koga, Mitsuhisa, Karube, Yoshiharu, Matsunaga, Kazuhisa, Takata, Jiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9102404/
https://www.ncbi.nlm.nih.gov/pubmed/35566078
http://dx.doi.org/10.3390/molecules27092727

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9102404/
https://www.ncbi.nlm.nih.gov/pubmed/35566078
http://dx.doi.org/10.3390/molecules27092727

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