Cargando…
Cationic N,N-Dimethylglycine Ester Prodrug of 2R-α-Tocotrienol Promotes Intestinal Absorption via Efficient Self-Micellization with Intrinsic Bile Acid Anion
The intestinal absorption of hydrophobic compounds is severely influenced by their transportation rate through the unstirred water layer in the intestinal lumen. A member of the vitamin E family, α-Tocotrienol (α-T3) has remarkable pharmacological effects, but its intestinal absorption is hampered d...
Autores principales: | Watase, Daisuke, Setoguchi, Shuichi, Nagata-Akaho, Nami, Goto, Shotaro, Yamakawa, Hirofumi, Yamada, Ayano, Koga, Mitsuhisa, Karube, Yoshiharu, Matsunaga, Kazuhisa, Takata, Jiro |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9102404/ https://www.ncbi.nlm.nih.gov/pubmed/35566078 http://dx.doi.org/10.3390/molecules27092727 |
Ejemplares similares
-
Novel Cationic Prodrug of Ubiquinol-10 Enhances Intestinal Absorption via Efficient Formation of Nanosized Mixed-Micelles with Bile Acid Anions
por: Setoguchi, Shuichi, et al.
Publicado: (2020) -
Growth Inhibitory Effects of Ester Derivatives of Menahydroquinone-4, the Reduced Form of Vitamin K(2(20)), on All-Trans Retinoic Acid-Resistant HL60 Cell Line
por: Yamakawa, Hirofumi, et al.
Publicado: (2021) -
Menahydroquinone-4 Prodrug: A Promising Candidate Anti-Hepatocellular Carcinoma Agent
por: Enjoji, Munechika, et al.
Publicado: (2015) -
Prodrugs for Skin Delivery of Menahydroquinone-4, an Active Form of Vitamin K(2(20)), Could Overcome the Photoinstability and Phototoxicity of Vitamin K(2(20))
por: Goto, Shotaro, et al.
Publicado: (2019) -
Antitumor Effects and Delivery Profiles of Menahydroquinone-4 Prodrugs with Ionic or Nonionic Promoiety to Hepatocellular Carcinoma Cells
por: Setoguchi, Shuichi, et al.
Publicado: (2018)