Cargando…

Identification of potential pathogenic genes for severe aplastic anemia by whole‐exome sequencing

BACKGROUND: Severe aplastic anemia (SAA) is a syndrome of severe bone marrow failure due to hyperfunction of CD8+ T cells. While, the genetic background of SAA is still unknown. In this study, we tried to explore the possible genetic variants in CD8+ T cells of SAA patients. METHODS: We performed wh...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Yang, Zhang, Yu, Ge, Hongyu, Li, Nianbin, Liu, Chunyan, Wang, Ting, Fu, Rong, Shao, Zonghong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9102512/ https://www.ncbi.nlm.nih.gov/pubmed/35435273 http://dx.doi.org/10.1002/jcla.24438

Ejemplares similares

Aplastic Anemia in China
por: Liu, Chunyan, et al.
Publicado: (2018)

Plasma Metabolomic and Intestinal Microbial Analyses of Patients With Severe Aplastic Anemia
por: Shao, Yuanyuan, et al.
Publicado: (2021)

Abnormal Proteomics Profile of Plasma Reveals the Immunological Pathogenesis of Severe Aplastic Anemia
por: Qi, Weiwei, et al.
Publicado: (2022)

PKM2 Is Required to Activate Myeloid Dendritic Cells from Patients with Severe Aplastic Anemia
por: Liu, Chunyan, et al.
Publicado: (2018)

Effects of Shikonin on the Functions of Myeloid Dendritic Cells in a Mouse Model of Severe Aplastic Anemia
por: Zheng, Mengying, et al.
Publicado: (2020)

Expression of C1q in the serum of patients with non-severe aplastic anemia, and its association with disease severity
por: Ding, Shaoxue, et al.
Publicado: (2019)

Abnormal expression of histone acetylases in CD8+ T cells of patients with severe aplastic anemia
por: Qi, Weiwei, et al.
Publicado: (2022)

Myeloid dendritic cells in severe aplastic anemia patients exhibit stronger phagocytosis
por: Sun, Yingying, et al.
Publicado: (2021)

Detection and Significance of CD4+CD25+CD127dim Regulatory T Cells in Individuals with Severe Aplastic Anemia
por: Qi, Weiwei, et al.
Publicado: (2015)

Bone Marrow Plasma Cytokine Signature Profiles in Severe Aplastic Anemia
por: Liu, Bingnan, et al.
Publicado: (2020)

Upregulated expression of leukocyte immunoglobulin-like receptor A3 in patients with severe aplastic anemia
por: Yu, Hong, et al.
Publicado: (2021)

The shortening telomere length of T lymphocytes maybe associated with hyper-function in servere aplastic anemia
por: Wang, Chaomeng, et al.
Publicado: (2018)

The Clinical and Immune Characteristics of Patients with Hepatitis-Associated Aplastic Anemia in China
por: Wang, Huaquan, et al.
Publicado: (2014)

Epstein Barr Virus Infection Affects Function of Cytotoxic T Lymphocytes in Patients with Severe Aplastic Anemia
por: Zhang, Tian, et al.
Publicado: (2018)

A cohort study of immune and hematopoietic functionality changes in severe aplastic anemia patients treated with immunosuppressive therapy
por: Guan, Jing, et al.
Publicado: (2019)

Successful sirolimus therapy of an aplastic anemia patient with chronic kidney disease: A case report
por: Niu, Haiyue, et al.
Publicado: (2020)

Granulocyte Transfusion Combined with Granulocyte Colony Stimulating Factor in Severe Infection Patients with Severe Aplastic Anemia: A Single Center Experience from China
por: Wang, Huaquan, et al.
Publicado: (2014)

Upregulated Expression of Profilin1 on Dendritic Cells in Patients With Severe Aplastic Anemia
por: Yu, Hong, et al.
Publicado: (2021)

Cofilin‐1 participates in the hyperfunction of myeloid dendritic cells in patients with severe aplastic anaemia
por: Sun, Yingying, et al.
Publicado: (2022)

Recombinant Human Thrombopoietin Treatment Promotes Hematopoiesis Recovery in Patients with Severe Aplastic Anemia Receiving Immunosuppressive Therapy
por: Wang, Huaquan, et al.
Publicado: (2015)

De-escalation empirical antibiotic therapy improved survival for patients with severe aplastic anemia treated with antithymocyte globulin
por: Fu, Rong, et al.
Publicado: (2017)

Efficacy and safety of avatrombopag in aplastic anemia patients with liver disease
por: Wang, Huaquan, et al.
Publicado: (2023)

Traditional Chinese medicine for treating aplastic anemia
por: Guan, Jing, et al.
Publicado: (2023)

P768: PRELIMINARY EXPLORATION ON LAG-3 EXPRESSION OF BONE MARROW-DERIVED MACROPHAGES IN SEVERE APLASTIC ANEMIA
por: Zhong, Congwei, et al.
Publicado: (2023)

P1353: EXPLORING A NOVEL TREATMENT STRATEGY FOR ACQUIRED APLASTIC ANEMIA TARGETING PPAR SIGNALING PATHWAY.
por: Yang, Liping, et al.
Publicado: (2023)

Relationship between immune status after ATG treatment and PNH clone evolution in patients with severe aplastic anemia
por: Wang, Honglei, et al.
Publicado: (2020)

Efficacy and safety of eltrombopag in Chinese patients with refractory or relapsed severe aplastic anemia
por: Chang, Hong, et al.
Publicado: (2023)

Severe Aplastic Anemia Presenting as Neutropenic Sepsis
por: Daniels, Natasha Faye, et al.
Publicado: (2020)

COVID-19 in children with severe aplastic anemia
por: Thakkar, Dhwanee, et al.
Publicado: (2022)

Massive eosinophilia despite severe aplastic anemia
por: Takahashi, Aya, et al.
Publicado: (2022)

Expression of Shelterin Component POT1 Is Associated with Decreased Telomere Length and Immunity Condition in Humans with Severe Aplastic Anemia
por: Wang, Ting, et al.
Publicado: (2014)

Very Severe Aplastic Anemia appearing after Thymectomy
por: Park, Chi Young, et al.
Publicado: (2003)

Spontaneously resolved severe retinopathy associated with aplastic anemia
por: Mal, Washoo, et al.
Publicado: (2021)

Bone marrow free immune checkpoints as a potential biomarker for differential diagnosis of acquired bone marrow failures
por: Zang, Mengtong, et al.
Publicado: (2022)

Nationwide survey on the use of eltrombopag in patients with severe aplastic anemia: a report on behalf of the French Reference Center for Aplastic Anemia
por: Lengline, Etienne, et al.
Publicado: (2018)

Hematopoietic Cell Transplantation with Cryopreserved Grafts for Severe Aplastic Anemia
por: Eapen, Mary, et al.
Publicado: (2020)

Idiopathic Aplastic Anemia: An Update
por: Solomou, Elena E.
Publicado: (2019)

Aplastic anemia in the elderly: a nationwide survey on behalf of the French Reference Center for Aplastic Anemia
por: Contejean, Adrien, et al.
Publicado: (2019)

Transfusion-dependent non-severe aplastic anemia: characteristics and outcomes in the clinic
por: Zhang, Yawen, et al.
Publicado: (2023)

Identification of novel regulators in T-cell differentiation of aplastic anemia patients
por: Franzke, Anke, et al.
Publicado: (2006)

Cannot write session to /tmp/vufind_sessions/sess_8nk1rj2j94vf43k1roiq8de3se