Cargando…

MicroRNA-145 Impairs Classical Non-Homologous End-Joining in Response to Ionizing Radiation-Induced DNA Double-Strand Breaks via Targeting DNA-PKcs

DNA double-strand breaks (DSBs) are one of the most lethal types of DNA damage due to the fact that unrepaired or mis-repaired DSBs lead to genomic instability or chromosomal aberrations, thereby causing cell death or tumorigenesis. The classical non-homologous end-joining pathway (c-NHEJ) is the ma...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sudhanva, Muddenahalli Srinivasa, Hariharasudhan, Gurusamy, Jun, Semo, Seo, Gwanwoo, Kamalakannan, Radhakrishnan, Kim, Hyun Hee, Lee, Jung-Hee
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9102532/ https://www.ncbi.nlm.nih.gov/pubmed/35563814 http://dx.doi.org/10.3390/cells11091509

Ejemplares similares

Inhibiting DNA-PKcs in a non-homologous end-joining pathway in response to DNA double-strand breaks
por: Dong, Jun, et al.
Publicado: (2017)

Inactivation of DNA-PK by knockdown DNA-PKcs or NU7441 impairs non-homologous end-joining of radiation-induced double strand break repair
por: Dong, Jun, et al.
Publicado: (2018)

Non-redundant Functions of ATM and DNA-PKcs in Response to DNA Double-Strand Breaks
por: Caron, Pierre, et al.
Publicado: (2015)

DNA-Dependent Protein Kinase Catalytic Subunit (DNA-PKcs): Beyond the DNA Double-Strand Break Repair
por: Lee, Ye-Rim, et al.
Publicado: (2023)

Targeting DNA double strand break repair with hyperthermia and DNA-PKcs inhibition to enhance the effect of radiation treatment
por: van Oorschot, Bregje, et al.
Publicado: (2016)

Preventing Damage Limitation: Targeting DNA-PKcs and DNA Double-Strand Break Repair Pathways for Ovarian Cancer Therapy
por: Dungl, Daniela A., et al.
Publicado: (2015)

Distinct roles of XRCC4 and Ku80 in non-homologous end-joining of endonuclease- and ionizing radiation-induced DNA double-strand breaks
por: Schulte-Uentrop, Leonie, et al.
Publicado: (2008)

Processing of DNA double strand breaks by alternative non-homologous end-joining in hyperacetylated chromatin
por: Manova, Vasilissa, et al.
Publicado: (2012)

Essential Factors for Incompatible DNA End Joining at Chromosomal DNA Double Strand Breaks In Vivo
por: Ogiwara, Hideaki, et al.
Publicado: (2011)

An Intrinsically Disordered APLF Links Ku, DNA-PKcs, and XRCC4-DNA Ligase IV in an Extended Flexible Non-homologous End Joining Complex
por: Hammel, Michal, et al.
Publicado: (2016)

The fructose-bisphosphate, Aldolase A (ALDOA), facilitates DNA-PKcs and ATM kinase activity to regulate DNA double-strand break repair
por: Sobanski, Thais, et al.
Publicado: (2023)

DNA-PK is activated by SIRT2 deacetylation to promote DNA double-strand break repair by non-homologous end joining
por: Head, PamelaSara E, et al.
Publicado: (2023)

Subdiffusion Supports Joining Of Correct Ends During Repair Of DNA Double-Strand Breaks
por: Girst, S., et al.
Publicado: (2013)

TNKS1BP1 functions in DNA double-strand break repair though facilitating DNA-PKcs autophosphorylation dependent on PARP-1
por: Zou, Lian-Hong, et al.
Publicado: (2015)

One end to rule them all: Non-homologous end-joining and homologous recombination at DNA double-strand breaks
por: Ensminger, Michael, et al.
Publicado: (2020)

Double Strand Break DNA Repair occurs via Non-Homologous End-Joining in Mouse MII Oocytes
por: Martin, Jacinta H., et al.
Publicado: (2018)

Extensive ssDNA end formation at DNA double-strand breaks in non-homologous end-joining deficient cells during the S phase
por: Karlsson, Karin H, et al.
Publicado: (2007)

Correction to ‘DNA-PK is activated by SIRT2 deacetylation to promote DNA double-strand break repair by non-homologous end joining’
Publicado: (2023)

Beta Human Papillomavirus 8E6 Attenuates Non-Homologous End Joining by Hindering DNA-PKcs Activity
por: Hu, Changkun, et al.
Publicado: (2020)

Non-Homologous End Joining Factors XLF, PAXX and DNA-PKcs Maintain the Neural Stem and Progenitor Cell Population
por: Gago-Fuentes, Raquel, et al.
Publicado: (2020)

Assays for DNA double-strand break repair by microhomology-based end-joining repair mechanisms
por: Kostyrko, Kaja, et al.
Publicado: (2016)

Plant organellar DNA polymerases repair double-stranded breaks by microhomology-mediated end-joining
por: García-Medel, Paola L, et al.
Publicado: (2019)

Hierarchy of nonhomologous end-joining, single-strand annealing and gene conversion at site-directed DNA double-strand breaks
por: Mansour, Wael Y., et al.
Publicado: (2008)

Non-Homologous End Joining and Homology Directed DNA Repair Frequency of Double-Stranded Breaks Introduced by Genome Editing Reagents
por: Zaboikin, Michail, et al.
Publicado: (2017)

In Silico Non-Homologous End Joining Following Ion Induced DNA Double Strand Breaks Predicts That Repair Fidelity Depends on Break Density
por: Henthorn, N. T., et al.
Publicado: (2018)

Translesion DNA synthesis-assisted non-homologous end-joining of complex double-strand breaks prevents loss of DNA sequences in mammalian cells
por: Covo, Shay, et al.
Publicado: (2009)

DNA-PKcs and Artemis function in the end-joining phase of immunoglobulin heavy chain class switch recombination
por: Franco, Sonia, et al.
Publicado: (2008)

Homologous recombination repairs secondary replication induced DNA double-strand breaks after ionizing radiation
por: Groth, Petra, et al.
Publicado: (2012)

TDP1 suppresses mis-joining of radiomimetic DNA double-strand breaks and cooperates with Artemis to promote optimal nonhomologous end joining
por: Kawale, Ajinkya S, et al.
Publicado: (2018)

Multi-pathway DNA-repair reporters reveal competition between end-joining, single-strand annealing and homologous recombination at Cas9-induced DNA double-strand breaks
por: van de Kooij, Bert, et al.
Publicado: (2022)

c-Fos-dependent miR-22 targets MDC1 and regulates DNA repair in terminally differentiated cells
por: Lee, Jung-Hee, et al.
Publicado: (2017)

Dual Roles for DNA Polymerase Theta in Alternative End-Joining Repair of Double-Strand Breaks in Drosophila
por: Chan, Sze Ham, et al.
Publicado: (2010)

Bridging of double-stranded breaks by the nonhomologous end-joining ligation complex is modulated by DNA end chemistry
por: Reid, Dylan A., et al.
Publicado: (2017)

Ku Regulates the Non-Homologous End Joining Pathway Choice of DNA Double-Strand Break Repair in Human Somatic Cells
por: Fattah, Farjana, et al.
Publicado: (2010)

CtIP and MRN promote non-homologous end-joining of etoposide-induced DNA double-strand breaks in G1
por: Quennet, Verena, et al.
Publicado: (2011)

Druggable binding sites in the multicomponent assemblies that characterise DNA double-strand-break repair through non-homologous end joining
por: Kefala Stavridi, Antonia, et al.
Publicado: (2020)

Human DNA ligases I and III, but not ligase IV, are required for microhomology-mediated end joining of DNA double-strand breaks
por: Liang, Li, et al.
Publicado: (2008)

DNA Double Strand Break Repair Pathways in Response to Different Types of Ionizing Radiation
por: van de Kamp, Gerarda, et al.
Publicado: (2021)

ZNF281 is recruited on DNA breaks to facilitate DNA repair by non-homologous end joining
por: Nicolai, Sara, et al.
Publicado: (2019)

Fission yeast CK1 promotes DNA double-strand break repair through both homologous recombination and non-homologous end joining
por: Cullati, Sierra N., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_844gb1r21l09mp54dbh63asv7a