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Inhibition of USP14 suppresses ferroptosis and inflammation in LPS-induced goat mammary epithelial cells through ubiquitylating the IL-6 protein

BACKGROUND: Ferroptosis, a novel manner of cell death depended on iron ion, contributed to goat mammary epithelial cell dysfunction. Interleukin-6 (IL-6) is a major pro-inflammatory factor during many inflammation-related diseases including mastitis, and a quite recently identified ferroptosis induc...

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Detalles Bibliográficos
Autores principales: Zhu, Guangqin, Sui, Shaopu, Shi, Fengyun, Wang, Qinglin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9102600/
https://www.ncbi.nlm.nih.gov/pubmed/35549778
http://dx.doi.org/10.1186/s41065-022-00235-y