Structure-Based Bioisosterism Design, Synthesis, Biological Evaluation and In Silico Studies of Benzamide Analogs as Potential Anthelmintics

A recent screen of 67,012 compounds identified a new family of compounds with excellent nematicidal activity: the ortho-substituted benzamide families Wact-11 and Wact-12. These compounds are active against Caenorhabditis elegans and parasitic nematodes by selectively inhibiting nematode complex II,...

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Detalles Bibliográficos
Autores principales: Vairoletti, Franco, Paulino, Margot, Mahler, Graciela, Salinas, Gustavo, Saiz, Cecilia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9102753/
https://www.ncbi.nlm.nih.gov/pubmed/35566007
http://dx.doi.org/10.3390/molecules27092659

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9102753/
https://www.ncbi.nlm.nih.gov/pubmed/35566007
http://dx.doi.org/10.3390/molecules27092659

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