A Phase I Trial to Determine the Safety and Tolerability of Autophagy Inhibition Using Chloroquine or Hydroxychloroquine in Combination With Carboplatin and Gemcitabine in Patients With Advanced Solid Tumors

BACKGROUND: Autophagy is a catabolic process that is triggered in cells during periods of metabolic or hypoxic stress, which enables their survival during this challenge. Autophagy may also impart survival advantage to tumors cells undergoing attack from chemotherapy or radiation. Inhibition of earl...

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Detalles Bibliográficos
Autores principales: Karim, Nagla Abdel, Ullah, Asad, Ahmad, Imran, Bahassi, Elmustapha, Olowokure, Olugbenga, Khaled, Ahmed, Davis, Harold, Morris, John C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9102974/
https://www.ncbi.nlm.nih.gov/pubmed/35574311
http://dx.doi.org/10.3389/fonc.2022.811411

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9102974/
https://www.ncbi.nlm.nih.gov/pubmed/35574311
http://dx.doi.org/10.3389/fonc.2022.811411

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