IFN-γ and TNF Induce Senescence and a Distinct Senescence-Associated Secretory Phenotype in Melanoma

Immune checkpoint blockade (ICB) therapy is a central pillar of melanoma treatment leading to durable response rates. Important mechanisms of action of ICB therapy include disinhibition of CD4(+) and CD8(+) T cells. Stimulated CD4(+) T helper 1 cells secrete the effector cytokines interferon-gamma (...

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Detalles Bibliográficos
Autores principales: Homann, Lorenzo, Rentschler, Maximilian, Brenner, Ellen, Böhm, Katharina, Röcken, Martin, Wieder, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9103004/
https://www.ncbi.nlm.nih.gov/pubmed/35563820
http://dx.doi.org/10.3390/cells11091514

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9103004/
https://www.ncbi.nlm.nih.gov/pubmed/35563820
http://dx.doi.org/10.3390/cells11091514

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