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IFN-γ and TNF Induce Senescence and a Distinct Senescence-Associated Secretory Phenotype in Melanoma

Immune checkpoint blockade (ICB) therapy is a central pillar of melanoma treatment leading to durable response rates. Important mechanisms of action of ICB therapy include disinhibition of CD4(+) and CD8(+) T cells. Stimulated CD4(+) T helper 1 cells secrete the effector cytokines interferon-gamma (...

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Detalles Bibliográficos
Autores principales:	Homann, Lorenzo, Rentschler, Maximilian, Brenner, Ellen, Böhm, Katharina, Röcken, Martin, Wieder, Thomas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9103004/ https://www.ncbi.nlm.nih.gov/pubmed/35563820 http://dx.doi.org/10.3390/cells11091514

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