Fraxinellone Induces Hepatotoxicity in Zebrafish through Oxidative Stress and the Transporters Pathway

Fraxinellone (FRA), a major active component from Cortex Dictamni, produces hepatotoxicity via the metabolization of furan rings by CYP450. However, the mechanism underlying the hepatotoxicity of FRA remains unclear. Therefore, zebrafish larvae at 72 h post fertilization were used to evaluate the me...

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Detalles Bibliográficos
Autores principales: Wang, Shuting, Bao, Jie, Li, Jie, Li, Wanfang, Tian, Mengyin, Qiu, Caixia, Pang, Fei, Li, Xin, Yang, Jianbo, Hu, Yuchi, Wang, Sujuan, Jin, Hongtao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9103149/
https://www.ncbi.nlm.nih.gov/pubmed/35566003
http://dx.doi.org/10.3390/molecules27092647

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9103149/
https://www.ncbi.nlm.nih.gov/pubmed/35566003
http://dx.doi.org/10.3390/molecules27092647

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