Dimerization Tendency of 3CLpros of Human Coronaviruses Based on the X-ray Crystal Structure of the Catalytic Domain of SARS-CoV-2 3CLpro

3CLpro of SARS-CoV-2 is a promising target for developing anti-COVID19 agents. In order to evaluate the catalytic activity of 3CLpros according to the presence or absence of the dimerization domain, two forms had been purified and tested. Enzyme kinetic studies with a FRET method revealed that the c...

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Detalles Bibliográficos
Autores principales: Jo, Seri, Kim, Hwa Young, Shin, Dong Hae, Kim, Mi-Sun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9103169/
https://www.ncbi.nlm.nih.gov/pubmed/35563658
http://dx.doi.org/10.3390/ijms23095268

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9103169/
https://www.ncbi.nlm.nih.gov/pubmed/35563658
http://dx.doi.org/10.3390/ijms23095268

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