Cargando…

Dimerization Tendency of 3CLpros of Human Coronaviruses Based on the X-ray Crystal Structure of the Catalytic Domain of SARS-CoV-2 3CLpro

3CLpro of SARS-CoV-2 is a promising target for developing anti-COVID19 agents. In order to evaluate the catalytic activity of 3CLpros according to the presence or absence of the dimerization domain, two forms had been purified and tested. Enzyme kinetic studies with a FRET method revealed that the c...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jo, Seri, Kim, Hwa Young, Shin, Dong Hae, Kim, Mi-Sun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9103169/ https://www.ncbi.nlm.nih.gov/pubmed/35563658 http://dx.doi.org/10.3390/ijms23095268

Ejemplares similares

A Study of 3CLpros as Promising Targets against SARS-CoV and SARS-CoV-2
por: Jo, Seri, et al.
Publicado: (2021)

Flavonoids with inhibitory activity against SARS-CoV-2 3CLpro
por: Jo, Seri, et al.
Publicado: (2020)

A Study of Drug Repurposing to Identify SARS-CoV-2 Main Protease (3CLpro) Inhibitors
por: Jo, Seri, et al.
Publicado: (2022)

Key dimer interface residues impact the catalytic activity of 3CLpro, the main protease of SARS-CoV-2
por: Ferreira, Juliana C., et al.
Publicado: (2022)

Biflavonoid as potential 3-chymotrypsin-like protease (3CLpro) inhibitor of SARS-Coronavirus
por: Hartini, Yustina, et al.
Publicado: (2021)

3CLpro inhibitors: DEL-based molecular generation
por: Xiong, Feng, et al.
Publicado: (2022)

Conformational Flexibility of a Short Loop near the Active Site of the SARS-3CLpro is Essential to Maintain Catalytic Activity
por: Li, Chunmei, et al.
Publicado: (2016)

Dimethyl sulfoxide reduces the stability but enhances catalytic activity of the main SARS‐CoV‐2 protease 3CLpro
por: Ferreira, Juliana C., et al.
Publicado: (2021)

Progress on SARS-CoV-2 3CLpro Inhibitors: Inspiration from SARS-CoV 3CLpro Peptidomimetics and Small-Molecule Anti-Inflammatory Compounds
por: Zhu, Jiajie, et al.
Publicado: (2022)

Inhibition by components of Glycyrrhiza uralensis of 3CLpro and HCoV-OC43 proliferation
por: Kim, Jang Hoon, et al.
Publicado: (2023)

Docking and Electronic Structure of Rutin, Myricetin, and Baicalein Targeting 3CLpro
por: Farias, Sergio A. de S., et al.
Publicado: (2023)

Crystal structure of the catalytic domain of botulinum neurotoxin subtype A3
por: Leka, Oneda, et al.
Publicado: (2021)

Biochemical and biophysical characterization of the main protease, 3-chymotrypsin-like protease (3CLpro) from the novel coronavirus SARS-CoV 2
por: Ferreira, Juliana C., et al.
Publicado: (2020)

Discovery of 3CLpro inhibitor of SARS-CoV-2 main protease
por: Kuang, Yi, et al.
Publicado: (2023)

A VSV-based assay quantifies coronavirus Mpro/3CLpro/Nsp5 main protease activity and chemical inhibition
por: Heilmann, Emmanuel, et al.
Publicado: (2022)

Computer-Aided Screening for Potential Coronavirus 3-Chymotrypsin-like Protease (3CLpro) Inhibitory Peptides from Putative Hemp Seed Trypsinized Peptidome
por: Prasertsuk, Kansate, et al.
Publicado: (2022)

A Crystal Structure of the Catalytic Core Domain of an Avian Sarcoma and Leukemia Virus Integrase Suggests an Alternate Dimeric Assembly
por: Ballandras, Allison, et al.
Publicado: (2011)

Crystal structures of human soluble guanylate cyclase catalytic domains: promiscuity of the dimer interface and a potential allosteric site
por: Gileadi, Opher, et al.
Publicado: (2013)

Structural and functional characterization of NEMO cleavage by SARS-CoV-2 3CLpro
por: Hameedi, Mikhail Ali, et al.
Publicado: (2021)

Sub-Micromolar Inhibition of SARS-CoV-2 3CLpro by Natural Compounds
por: Rizzuti, Bruno, et al.
Publicado: (2021)

Structural and functional characterization of NEMO cleavage by SARS-CoV-2 3CLpro
por: Hameedi, Mikhail A., et al.
Publicado: (2022)

Development of Highly Potent Noncovalent Inhibitors of SARS-CoV-2 3CLpro
por: Hou, Ningke, et al.
Publicado: (2023)

pH profiles of 3-chymotrypsin-like protease (3CLpro) from SARS-CoV-2 elucidate its catalytic mechanism and a histidine residue critical for activity
por: Al Adem, Kenana, et al.
Publicado: (2022)

Role of the nucleotidyl cyclase helical domain in catalytically active dimer formation
por: Vercellino, Irene, et al.
Publicado: (2017)

Crystal structure of the N-terminal domain of MinC dimerized via domain swapping
por: An, Jun Yop, et al.
Publicado: (2013)

Peptidomimetic Small-Molecule Inhibitors of 3CLPro Activity and Spike–ACE2 Interaction: Toward Dual-Action Molecules against Coronavirus Infections
por: Tedesco, Filomena, et al.
Publicado: (2022)

Crystal Structure of Human Nocturnin Catalytic Domain
por: Estrella, Michael A., et al.
Publicado: (2018)

Computational Studies of SARS-CoV-2 3CLpro: Insights from MD Simulations
por: Grottesi, Alessandro, et al.
Publicado: (2020)

Development of a colorimetric assay for the detection of SARS-CoV-2 3CLpro activity
por: Garland, Gavin D., et al.
Publicado: (2022)

Identification of 3-chymotrypsin like protease (3CLPro) inhibitors as potential anti-SARS-CoV-2 agents
por: Mody, Vicky, et al.
Publicado: (2021)

The inhibitory activity of methoxyl flavonoids derived from Inula britannica flowers on SARS-CoV-2 3CLpro
por: Kim, Jang Hoon, et al.
Publicado: (2022)

Crystal structure of the WD40 domain dimer of LRRK2
por: Zhang, Pengfei, et al.
Publicado: (2019)

Structure-based design, synthesis, and biological evaluation of peptidomimetic SARS-CoV 3CLpro inhibitors
por: Ghosh, Arun K., et al.
Publicado: (2007)

Structural stability of SARS-CoV-2 3CLpro and identification of quercetin as an inhibitor by experimental screening
por: Abian, Olga, et al.
Publicado: (2020)

Natural Products-Based Drug Design against SARS-CoV-2 Mpro 3CLpro
por: Silva, Rai C., et al.
Publicado: (2021)

BRET-Based Self-Cleaving Biosensors for SARS-CoV-2 3CLpro Inhibitor Discovery
por: Hou, Ningke, et al.
Publicado: (2022)

Inhibition of SARS-CoV 3CL protease by flavonoids
por: Jo, Seri, et al.
Publicado: (2019)

A viral RNA-dependent RNA polymerase inhibitor VV116 broadly inhibits human coronaviruses and has synergistic potency with 3CLpro inhibitor nirmatrelvir
por: Zhang, Yumin, et al.
Publicado: (2023)

Epigallocatechin-3-gallate, an active ingredient of Traditional Chinese Medicines, inhibits the 3CLpro activity of SARS-CoV-2
por: Du, Ashuai, et al.
Publicado: (2021)

Catalytic trajectory of a dimeric nonribosomal peptide synthetase subunit with an inserted epimerase domain
por: Wang, Jialiang, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_orupq54as4l8kdlp3ap959ur2r