Cargando…

Design, Synthesis, and Biological Evaluation of Novel MAO-A Inhibitors Targeting Lung Cancer

Lung cancer is one of the most common causes of cancer-related deaths worldwide. Monoamine Oxidase-A (MAO-A) enzyme mediates the production of reactive oxygen species (ROS) that trigger DNA damage and oxidative injury of cells resulting in tumor initiation and progression. Available MAO-A inhibitors...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bardaweel, Sanaa, Aljanabi, Reem, Sabbah, Dima, Sweidan, Kamal
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9103226/ https://www.ncbi.nlm.nih.gov/pubmed/35566238 http://dx.doi.org/10.3390/molecules27092887

Ejemplares similares

Monoamine Oxidase (MAO) as a Potential Target for Anticancer Drug Design and Development
por: Aljanabi, Reem, et al.
Publicado: (2021)

N-phenyl-6-chloro-4-hydroxy-2-quinolone-3-carboxamides: Molecular Docking, Synthesis, and Biological Investigation as Anticancer Agents
por: Sabbah, Dima A., et al.
Publicado: (2020)

Molecular Modeling, Synthesis and Biological Evaluation of N-Phenyl-4-Hydroxy-6-Methyl-2-Quinolone-3-CarboxAmides as Anticancer Agents
por: Sabbah, Dima A., et al.
Publicado: (2020)

Design, Synthesis and Biological Evaluation of Novel N-Pyridyl-Hydrazone Derivatives as Potential Monoamine Oxidase (MAO) Inhibitors
por: Turan-Zitouni, Gülhan, et al.
Publicado: (2018)

Chemocentric Informatics Analysis: Dexamethasone Versus Combination Therapy for COVID-19
por: Hajjo, Rima, et al.
Publicado: (2020)

Targeting Human Proteins for Antiviral Drug Discovery and Repurposing Efforts: A Focus on Protein Kinases
por: Hajjo, Rima, et al.
Publicado: (2023)

Novel amphiphilic pyridinium ionic liquids-supported Schiff bases: ultrasound assisted synthesis, molecular docking and anticancer evaluation
por: Al-Blewi, Fawzia Faleh, et al.
Publicado: (2018)

Shedding the Light on Post-Vaccine Myocarditis and Pericarditis in COVID-19 and Non-COVID-19 Vaccine Recipients
por: Hajjo, Rima, et al.
Publicado: (2021)

Identification of Tumor-Specific MRI Biomarkers Using Machine Learning (ML)
por: Hajjo, Rima, et al.
Publicado: (2021)

Design, Synthesis, and Biological Evaluation of Pyridazinones Containing the (2-Fluorophenyl) Piperazine Moiety as Selective MAO-B Inhibitors
por: Çeçen, Muhammed, et al.
Publicado: (2020)

Design and Synthesis of New Benzothiazole Compounds as Selective hMAO-B Inhibitors
por: Ilgın, Sinem, et al.
Publicado: (2017)

Structure-Based Design of Novel MAO-B Inhibitors: A Review
por: Mateev, Emilio, et al.
Publicado: (2023)

Inhibitors of MAO-A and MAO-B in Psychiatry and Neurology
por: Finberg, John P. M., et al.
Publicado: (2016)

Novel Matrix Metalloproteinase-9 (MMP-9) Inhibitors in Cancer Treatment
por: Rashid, Zainab Ahmed, et al.
Publicado: (2023)

Synthesis and Preliminary Biological Evaluation of 1,3,5-Triazine Amino Acid Derivatives to Study Their MAO Inhibitors
por: Khattab, Sherine N., et al.
Publicado: (2015)

MAO-inhibitors in Parkinson's Disease
por: Riederer, Peter, et al.
Publicado: (2011)

Reversible Small Molecule Inhibitors of MAO A and MAO B with Anilide Motifs
por: Hagenow, Jens, et al.
Publicado: (2020)

Design, Synthesis, In Vitro and In Silico Studies of New Thiazolylhydrazine-Piperazine Derivatives as Selective MAO-A Inhibitors
por: Sağlık, Begüm Nurpelin, et al.
Publicado: (2020)

Molecular Investigation of the Antitumor Effects of Monoamine Oxidase Inhibitors in Breast Cancer Cells
por: Alkhawaldeh, Aseel, et al.
Publicado: (2023)

Novel Thiosemicarbazone Derivatives: In Vitro and In Silico Evaluation as Potential MAO-B Inhibitors
por: Osmaniye, Derya, et al.
Publicado: (2021)

Design, Synthesis and Biological Evaluation of Novel MDH Inhibitors Targeting Tumor Microenvironment
por: Godesi, Sreenivasulu, et al.
Publicado: (2023)

Coumarin-Chalcone Hybrids as Inhibitors of MAO-B: Biological Activity and In Silico Studies
por: Moya-Alvarado, Guillermo, et al.
Publicado: (2021)

Redefining differential roles of MAO-A in dopamine degradation and MAO-B in tonic GABA synthesis
por: Cho, Hyun-U, et al.
Publicado: (2021)

Synthesis of Novel Benzo[b][1,6]naphthyridine Derivatives and Investigation of Their Potential as Scaffolds of MAO Inhibitors
por: Kulikova, Larisa N., et al.
Publicado: (2023)

Recent Advances in the Synthesis and Biological Activity of 8-Hydroxyquinolines
por: Saadeh, Haythem A., et al.
Publicado: (2020)

Maó
por: Quintana, Josep M. (Josep Maria)
Publicado: (1996)

Novel Dipyridinium Lipophile-Based Ionic Liquids Tethering Hydrazone Linkage: Design, Synthesis and Antitumorigenic Study
por: Al-Sodies, Salsabeel, et al.
Publicado: (2021)

Rasagiline – a novel MAO B inhibitor in Parkinson’s disease therapy
por: Lecht, Shimon, et al.
Publicado: (2007)

Mao : a biography /
por: Terrill, Ross
Publicado: (1981)

Computationally Assisted Lead Optimization of Novel Potent and Selective MAO-B Inhibitors
por: Gogineni, Vedanjali, et al.
Publicado: (2021)

Development of a Novel Class of Pyridazinone Derivatives as Selective MAO-B Inhibitors
por: Alagöz, Mehmet Abdullah, et al.
Publicado: (2022)

Mao Zedong
por: Grimm, Tilemann
Publicado: (1986)

Microwave Assisted Organic Synthesis (MAOS) of Small Molecules as Potential HIV-1 Integrase Inhibitors
por: Ferro, Stefania, et al.
Publicado: (2011)

Chemical and Biological Evaluation of Novel 1H-Chromeno[3,2-c]pyridine Derivatives as MAO Inhibitors Endowed with Potential Anticancer Activity
por: Kulikova, Larisa N., et al.
Publicado: (2023)

Design, Synthesis and Anticancer Screening of Novel Benzothiazole-Piperazine-1,2,3-Triazole Hybrids
por: Aouad, Mohamed R., et al.
Publicado: (2018)

Design, synthesis, ADME prediction and pharmacological evaluation of novel benzimidazole-1,2,3-triazole-sulfonamide hybrids as antimicrobial and antiproliferative agents
por: Al-blewi, Fawzia Faleh, et al.
Publicado: (2018)

The Development and Application of Novel IR and NMR-Based Model for the Evaluation of Carminative Effect of Artemisia judaica L. Essential Oil
por: Alzweiri, Muhammed, et al.
Publicado: (2014)

4-(3-Nitrophenyl)thiazol-2-ylhydrazone derivatives as antioxidants and selective hMAO-B inhibitors: synthesis, biological activity and computational analysis
por: Secci, Daniela, et al.
Publicado: (2019)

Synthesis of New Hydrazone Derivatives for MAO Enzymes Inhibitory Activity
por: Can, Nafiz Öncü, et al.
Publicado: (2017)

Correction: Saadeh et al. Recent Advances in the Synthesis and Biological Activity of 8-Hydroxyquinolines. Molecules 2020, 25, 4321
por: Saadeh, Haythem A., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_osdbn3vj1ro5is6410binvo89j